Study on the Mechanism of Prevotella Copri Promoting the Occurrence and Development of Atherosclerosis
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Concentration of Brain Natriuretic Peptide
研究概览
简要总结
Mainly studying the correlation between the abundance of Prevotella copri （P.copri） in the gut microbiome and the progression of clinical coronary atherosclerotic heart disease（CAD） patients, and confirming that an increase in P.copri abundance will accelerate the occurrence and development of CAD disease, accompanied by an increase in serum Branched chain amino acid（BCAA）, lipopolysaccharide（LPS）, and serotonin; For people who mainly consume a high carbon water diet, blood sugar is a stronger risk factor for AS compared to blood lipids; Explore the KAP status（Study composes of Knowledge, attitude, and practice） of coronary heart disease patients and their caregivers regarding coronary heart disease and diet, and investigate whether the popularization of science after KAP investigation can change the treatment effect of patients.
详细描述
Confirming the progression of coronary heart disease in patients and the proportion of P.copri in the gut microbiome; Confirming that due to the increased abundance of P.copri, factors related to blood glucose metabolism disorders are more associated with the progression of CAD disease compared to lipid factors; Confirming that P.copri induces insulin resistance and inflammation in the body while altering intestinal permeability through the synthesis of BCAA, LPS, and serotonin;; Through controlled experiments conducted at our center, investigators effectively popularized disease science to patients and their caregivers, promoted their participation in disease treatment, and confirmed that the KAP survey method can optimize patient treatment effectiveness, improve doctor-patient relationships, and enhance patient hospitalization experience. Through this research project, investigators explore the application of KAP research in the form of a questionnaire in this discipline. Through KAP research, investigators aim to popularize knowledge about dietary patterns and coronary heart disease among multi center coronary heart disease patients and their caregivers. investigators also investigate the "knowledge", "belief", and "behavior" of current coronary heart disease patients and their caregivers regarding coronary heart disease diagnosis and treatment knowledge, and conduct a knowledge lecture, Establish a new model for mastering, attitudes, and actions related to the diagnosis and treatment of coronary heart disease among patients and their accompanying caregivers through data push and other forms, while also providing theoretical and practical basis for subsequent related research. Through this project, investigators will discuss the feasibility of KAP survey in increasing patients' subjective initiative, improving doctor-patient relationships, and promoting the effectiveness of patient treatment. investigators will also discuss its promotion and inclusion in routine diagnostic and treatment methods.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Treatment
- 盲法
- Single (Care Provider)
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Atherosclerosis mechanism research: diagnosis is made through clinical diagnostic technical indicators, mainly coronary CT or coronary angiography. Experimental group: patients with coronary heart disease are identified; Control group: Admitted patients without coronary heart disease but may have other heart diseases or risk factors; Age:>50 years old
- •KAP Study: Coronary Heart Disease Patients and Their Families
排除标准
- •Atherosclerosis mechanism research: age<50 years old; Patients with a history of coronary heart disease or surgery; Patients with systemic diseases, including liver and kidney diseases (with serum creatinine levels>2mg/dL (176.8 μ Mol/dL), collagen diseases, etc; Patients who have been using antibiotics within the past 6 months; Patients with malignant tumor disease
- •KAP Study: Non coronary heart disease patients and their caregivers
结局指标
主要结局
Concentration of Brain Natriuretic Peptide
时间窗: Within 7 days after surgery
Blood sampling and testing
Concentration of myocardial enzyme
时间窗: Within 7 days after surgery
Blood sampling and testing
left ventricular end systolic diameter
时间窗: 7 days before surgery
Ultrasonic instrument exploration
pulmonary artery pressure
时间窗: Within 7 days after surgery
Ultrasonic instrument exploration
Concentration of troponin
时间窗: Within 7 days after surgery
Blood sampling and testing
questionnaire1
时间窗: Within 7 days after admission
KAP scale，This questionnaire consists of a total of 25 questions, with the first 7 questions being the baseline survey of the subjects, which facilitates statistical information without involving scores. The remaining questions consist of 10 knowledge questions (each desired response was scored 1, maximum K-score was 10), 5 attitude questions (each desired response was scored 1, maximum A-score was 5), and 3 practice questions (this question consists of 5 options, depending on frequency or severity, 1 is obtained when selecting 1 or 2 options, 2 is obtained when selecting 3 options, 3 is obtained when selecting 4 or 5 options, and 5 is obtained when selecting maximum P-score was 5)，higher scores mean a better outcome
questionnaire2
时间窗: Within 7 days after surgery
Composed of 5 questions, choose the expected answer and add 1 point. The higher the score, the better
Prevotella copri abundance
时间窗: through study completion, an average of 1 year
16S ribosomal DNA identification sequencing of feces
left ventricular size
时间窗: 7 days before surgery
Ultrasonic instrument exploration
Concentration of branched chain amino acids
时间窗: through study completion, an average of 1 year
Blood sampling and testing
Concentration of serotonin
时间窗: through study completion, an average of 1 year
Blood sampling and testing
lipopolysaccharides
时间窗: through study completion, an average of 1 year
Blood sampling and testing
Concentration of blood glucose
时间窗: through study completion, an average of 1 year
Blood sampling and testing
Concentration of lipids
时间窗: through study completion, an average of 1 year
Blood sampling and testing
cardiac ejection fraction
时间窗: 7 days before surgery
Ultrasonic instrument exploration
ejection volume
时间窗: Within 7 days after surgery
Ultrasonic instrument exploration
end diastolic diameter
时间窗: Within 7 days after surgery
Ultrasonic instrument exploration
次要结局
未报告次要终点
研究者
Hai Tian
Clinical Professor
The Second Affiliated Hospital of Harbin Medical University