Transthoracic Ultrasound in the Diagnosis and Follow-up of Ventilator Associated Pneumonia

Not Applicable

• Conditions: Lung Ultrasound; Ventilator Associated Pneumonia

• Registration Number: NCT04057625
• Lead Sponsor: Assiut University

Brief Summary

To evaluate the sensitivity, specificity and diagnostic accuracy of bedside transthoracic ultrasound examination in the diagnosis and follow up of ventilator associated pneumonia.

Detailed Description

VAP is the most frequent hospital-acquired infection in intensive care units. Depending on the diagnostic criteria used, its incidence ranges from 5% to 67%. The risk of acquiring VAP is 3% per day during the first 5 days on mechanical ventilation, and it is decreased to 1% per day for the following days.

VAP is suspected when subject shows high grade fever, increase in leukocyte count, change in color of sputum and tachypnea. It's a leading cause of mortality in 15- 65% of the cases.

Serial chest x-ray for diagnosis and follow up, done at time of diagnosis, after 5 days and after 10 days. Chest radiography is consistently carried out after LUS , LUS is done every other day, measuring the largest area of consolidation according to the intercostal space and direction of the probe . Chest radiography is read by two physicians.

Study Timeline

• Status Verified: 2019-08
• Study First Submitted: 2019-08-14
• Study First Submitted QC: 2019-08-14
• Study First Posted: 2019-08-15
• Last Update Submitted: 2019-08-22
• Last Update Posted: 2019-08-26
• Study Start: 2019-09
• Primary Completion: 2020-09
• Study Completion: 2020-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

• Mechanical ventilation for at least 48 hours.
• New or evolving infiltrate on chest radiograph (CXR).
• Clinical pulmonary infection score more than or equal 6

Exclusion Criteria

• Patients who are less than 18 years old.
• Patients who have evidence of pneumonia before or prior to being mechanically ventilated.
• Patients with pulmonary infarction.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
detecting ultrasound efficiency in diagnosis and follow up of vap	baseline	Sensitivity, specificity, and diagnostic accuracy of lung ultrasound to diagnose and follow up ventilator-associated pneumonia.

Secondary Outcome Measures

Name	Time	Method
icu stay	baseline	Duration of stay in ICU.
hospital stay	basline	Duration of hospital stay.
mortality	basline	mortality from vap