Integrating Systematic Data of Geriatric Medicine to Explore the Solution for Health Aging
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- The monitoring of sleep-related events of local Taiwanese aged over 60 years old
研究概览
简要总结
This project aims to build up the comprehensive database of geriatric medicine for local Taiwanese.
详细描述
This project is the pilot for the basis of establishing the schema of database and efficient procedures including subject recruitment, specimen collection, management, and measurement of samples obtained from multiple sources. We will focus on deciphering the correlation of sleep quality and the integrity of brain structure by integrating the holistic health data, socio-demographic characteristics, MRI, wearable technique, and laboratory technology including clinical lab, genotyping, metabolomics, gut microbiome, to unravel the clinical feature of which the age will effect on the frequency of sleep disturbance. This project will not only systematically study the aging effect on the sleep quality and brain structure integrity, but pave the way for exploring a variety of aging-related indications.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants of annual health checkup conducted by either Taipei city or Chang Gung Health and Culture Village.
- •aged ≧ 60 years old.
- •have medical record in Chang Gung Memorial Hospital.
- •resided in the Taiwan area over 180 days in past one year.
排除标准
- •Participants with the medical history of severe organ disorders, severe autoimmune disease, or cancer under treatment.
- •Contraindications or previously failure for receiving brain computerized tomography or magnetic resonance imaging scan.
- •Participants who had receive outpatient clinic follow-ups with diseases that may affect the cognitive evaluation or presentation.
- •Depression with ongoing diagnosis and treatment, suicide idea or suicide behavior in the past 6 months.
- •Difficulty in communication or disabilities
结局指标
主要结局
The monitoring of sleep-related events of local Taiwanese aged over 60 years old
时间窗: one night
Measure the sleep stages (unit in minute), apnea-hypopnea index (unit in counts/hour), and respiratory events by polysomnography
The brain volume of local Taiwanese aged over 60 years old
时间窗: one hour
Measure the volume of cerebrum, cerebellum, and skin of skull (unit in mm3) by magnetic resonance imaging (MRI)
次要结局
- The actigraphy of local Taiwanese aged over 60 years old(two weeks)
- The gut microbiota of local Taiwanese aged over 60 years old(one day)
- The neurocognitive questionnaire of local Taiwanese aged over 60 years old(one day)
- The metabolism of local Taiwanese aged over 60 years old(one day)
- The polysomnographic recording for elderly with obstructive sleep apnea (OSA)(three months)