The Optimal Timing of Carbon Dioxide Insufflation During Colonoscopy in Unsedated Patients
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Tri-Service General Hospital
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- abdominal pain during and after colonoscopy
Study Overview
Brief Summary
Insufflation of carbon dioxide (CO2) instead of air can reduce pain resulting from colon distension after colonoscopy because CO2 is rapidly absorbed from the colon and excreted through the lungs. This reduces the effects of colonic distension and minimizes intracolonic gas at the end of the examination. The aims of the study were to evaluate the timing of administering CO2 insufflation and to identify predictors of discomfort for colonoscopy.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Health Services Research
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •patients with an appropriate indication for colonoscopy were considered eligible.
Exclusion Criteria
- •Exclusion criteria included severe hematochezia, acute colonic pseudo-obstruction, known obstructive lesions, age <18 years, prior colon resection, fulminant colitis, chronic obstructive pulmonary disease requiring oxygen, and a medical history of CO2 retention. Patients that required only a partial colonoscopy or were unable to read or understand Chinese were also excluded.
Arms & Interventions
Insertion without CO2 insufflation
Patients were randomly allocated to receive whole procedure or extubation-only CO2 insufflation, using a randomized computer-generated list.
Intervention: Insufflation with CO2 (Procedure)
Insertion with CO2
Patients were randomly allocated to receive whole procedure or extubation-only CO2 insufflation, using a randomized computer-generated list.
Intervention: Insufflation with CO2 (Procedure)
Outcomes
Primary Outcomes
abdominal pain during and after colonoscopy
Time Frame: One day
Pain was recorded on a ten-point visual analog scale (0- no pain, 10- worst imaginable pain) at left-sided colonoscopic insertion, right-sided colonoscopic insertion, and at 1, 3, 6, and 24 hours postprocedure.
Secondary Outcomes
- delayed bleeding(One day)
- colonoscopic cecal intubation time(One day)
- completeness of intubation(One day)
- loop formation(One day)
Investigators
Peng-Jen Chen
Dr.
Tri-Service General Hospital