Effect of cardiac drug ivabradine on heart rate and blood pressure stability in patients undergoing off pump Coronary Artery Bypass surgery.
Not Applicable
Completed
- Conditions
- Health Condition 1: null- patients with coronary artery disease who have to undergo coronary artery bypass grafting under general anaesthesia
- Registration Number
- CTRI/2015/06/005858
- Lead Sponsor
- G B Pant Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
2)primary CABG
3)Left ventricular Ejection Fraction 45% or more
Exclusion Criteria
•HR <60 beats/min
•Emergency surgery.
•NYHA class IV.
•Redo surgery.
•Stroke or transient ischaemic attack
•Implanted defibrillator, cardioverter or pacemaker
•Associated valvular heart disease
•Sick sinus syndrome
•Sino-atrial block
•Congenital long QT
•Complete atrioventricular block
•Severe or uncontrolled hypertension
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method heart rate, systolic blood pressure,diastolic blood pressure,mean blood pressureTimepoint: every 10 minutes from induction till start of coronary anastomosis.during coronary anastomosis every 5 minutes. after anastomosis evey 10 minutes till the closure of chest.
- Secondary Outcome Measures
Name Time Method level of troponin T and Brain Natriuretic PeptideTimepoint: 12 hours postoperatively;morbidity and mortalityTimepoint: upto 30 days from date of operation;time to extubateTimepoint: after shifting in icu;untoward incidences like arrthymias or arrestTimepoint: till the patient in the hospital;central venous pressure , mean pulmonary arterial pressure, pulmonary capillary wedge pressure,stroke index, cardiac index, systemic vascular resistance index,pulmonary vascular resistance index, left ventricular stroke work index,right ventricular stroke work index,mixed venous oxygen saturationTimepoint: before induction,3 minutes after induction, 1 and 3 minutes after intubation,5 and 30 minutes after protamine