Prospective multicenter study on the quantitative pathophysiological assessment of acute pulmonary edema
Not Applicable
- Conditions
- acute pulmonary edema
- Registration Number
- JPRN-UMIN000003627
- Lead Sponsor
- Tohoku University Graduate School of Medicine
- Brief Summary
Main results were published in the following manuscripts; Critical Care 2012, 16:R232 Critical Care 2013; 17:R132 Critical Care 2013; 17:418
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
Not provided
Exclusion Criteria
1) Over 5 days from the onset of acute respiratory failure with PaO2 /FIO2 ratio < 300 2) Chronic respiratory insufficiency (COPD, et al) 3) After pulmonary resection / pneumonectomy 4) Pulmonary thromboembolism 5) Severe peripheral arterial disease (ASO, et al) 6) Cardiogenic shock with cardiac index < 1.5 L/min/m2 7) Inappropriate for evaluation with transpulmonary thermodilution technique 8) Attending physician's decision for inappropriateness for inclusion
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To establish the quantitative differential criteria of cardiogenic edema and ALI/ARDS (permeability edema), using pulmonary vascular permeability index (PVPI) and extravascular lung water index (ELWI).
- Secondary Outcome Measures
Name Time Method 1) Effects of serum albumin level and osmolarity on ELWI 2) Assessment of the relationship between PVPI and capillary leak index 3) Effect of selective neutrophil elastase inhibitor on patients with acute pulmonary edema 4) Assessment of severity and prognosis using ELWI, PVPI, and plasma antithrombin activity 5) Prognostic value of ELWI calculated from predicted body weight 6) Differences of EVLW and PVPI between direct and indirect injury 7) Relationship between serum BNP, NT-proBNP, creatinine and ELWI, PVPI. 8) Relationship between DIC and ELWI, PVPI 9) Relationship between ELWI, PVPI and 28-day mortarityl, period of time on mechanical ventilation. 10) Relationship between ELWI, PVPI measured at the onset of acute pulmonary edema and quasi-static lung compliance, PEEP level. 11)Relationship between procalcitonin, acutephase reactants and ELWI, PVPI