NCT01373840已完成不适用
Role of Dopamine Receptors in Primary Focal Dystonias
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
研究概览
简要总结
Dystonia is a disabling movement disorder characterized by repetitive patterned or sustained muscle contractions causing twisting or abnormal postures that may afflict 250,000 people in the U.S. While the pathophysiology of dystonia remains uncertain the treatment is rather rudimentary. A better understanding of neural mechanisms of dystonias is not only an invaluable prerequisite for developing better treatment options but also a step toward better understanding of the complex network of basal ganglia. In this study I will investigate if there is any difference between the dopamine receptors and dopamine in people with dystonia and healthy subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or Female
- •Any race or ethnicity
- •Primary focal dystonia (arm or cranial)
- •Ability to give informed consent
- •Exclusion criteria:
- •Family history of dystonia
- •Pregnancy (confirmed with negative urine pregnancy test in women of child bearing potential), breastfeeding
- •Exposure to radiation therapy
- •Any MRI contraindications such as foreign metallic implants, pacemaker, and aneurysm clip etc.
- •History of cardiac disease, uncontrolled hypertension, abnormal EKG during screening phase
- •History of exposure to any drugs affecting dopaminergic systems within the last 6 months (e.g. dopamine receptor blocking agents, cocaine, amphetamine, tetrabenazine, reserpine, L-dopa, dopamine agonists, as they might affect the dopamine receptor binding or endogenous dopamine).
- •Active depression (Beck Depression Inventory_II >14)
- •Cognitive impairment (Mini-Mental State Score <27)
- •CNS active medications such as gabapentin or narcotics, muscle relaxants which might be given for pain in the 3 days prior to study
- •History of stroke, seizure, cerebral palsy, generalized dystonia, parkinsonism, inability to hold head still during the scanning time.
排除标准
- 未提供
研究者
研究点 (1)
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