Whole Body Magnetic Resonance Angiography With Subsystolic Venous Compression
- Conditions
- AtherosclerosisIntermittent Claudication
- Registration Number
- NCT00560534
- Lead Sponsor
- Copenhagen University Hospital at Herlev
- Brief Summary
To investigate the diagnostic performance of whole body magnetic resonance angiography (WB-MRA) using subsystolic venous compression of the thigh.
- Detailed Description
WB-MRA is an examination that can evaluate the arteries from head to feet. Timing of the injected bolus of contrast medium can be difficult, especially in the legs. As the result of the WB-MRA depends on the contrast medium only being in the arteries at the time of examination, the use of venous compression is a possible way of overcoming the problem of early venous filling, that can hamper the diagnostic value of the examination. Venous compression is performed with a blod pressure cuff around the thighs. It is inflated to subsystolic pressure (45 mm Hg). This elevated pressure leads to filling of the lower leg arteries and late venous filling.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 36
- Symptomatic lower extremity ischemia (claudication, ischemic wounds)
- Referred to digital subtraction angiography (DSA)
- Renal insufficiency (GFR < 30 ml/min)
- Contra-indications for MRI-examination (claustrophobia, metal-implants, pacemaker)
- Dementia
- Pregnancy/lactation
- Allergy to gadolinium based MRI contrast agents
- Acute disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Vascular diagnostic quality on the WB-MRA. Degree of arterial stenosis on the WB-MRA 1 month
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Radiology, Herlev University Hospital
🇩🇰Herlev Copenhagen, Herlev, Denmark