Study to Assess the Efficacy of Ipratropium Bromide Associated With High Dose Salbutamol by Repeated Nebulisation Versus Repeat Nebulisation of Salbutamol Alone, in Acute Asthmatic Attacks in Young Children
Phase 4
Terminated
- Conditions
- Asthma
- Interventions
- Registration Number
- NCT02235428
- Lead Sponsor
- Boehringer Ingelheim
- Brief Summary
To determine whether addition of ipratropium bromide to salbutamol nebulisations produces significantly greater bronchodilation in young children presenting to an emergency department with an acute attack of asthma
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 3
Inclusion Criteria
- Boys or girls between 3 and 6 years old
- Presenting to emergency departments with an acute asthmatic attack
- Requiring nebulised bronchodilator therapy
- Rint increased by 200 % compared to theoretical Rint
- Signed, informed consent obtained from the child's parents/legal guardian in accordance with current national legislation and good clinical practice (GCP) defined by the International Conference on Harmonization (ICH)
Exclusion Criteria
- Ipratropium bromide received within four hours before admission
- First acute asthmatic attack
- Hospital admission to intensive care with asthma within six months before inclusion
- Hospital admission for asthma during the month prior to inclusion
- Corticosteroid-dependent asthma (oral corticosteroid therapy) or recently stopped corticosteroid therapy
- Concomitant cardiac disease
- Life threatening disease requiring immediate management; including: silent chest on auscultation, cyanosis, bradycardia less than 60 beats/min (bpm), confusion, coma
- Hypersensitivity to ipratropium bromide, salbutamol, or to any of their excipients
- Renal or hepatic insufficiency
- Poorly controlled diabetes
- Patients suffering from a disease considered to be severe by the investigator and which, in the opinion of the investigator, could interfere or invalidate the measurements performed in the trial
- Past history of lung surgery
- Major respiratory disease: pulmonary fibrosis, bronchiectasis, sarcoidosis, tuberculosis, respiratory disease due to AIDS, cystic fibrosis
- Patients unable to follow with protocol or correctly undergo the evaluations
- Patients who are taking part in another clinical trial during this trial or who have done so within the month before the trial
- Previous participation in this trial
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Salbutamol Placebo - Ipratropium bromide Ipratropium bromide - Ipratropium bromide Salbutamol - Salbutamol Salbutamol -
- Primary Outcome Measures
Name Time Method Changes from baseline in pulmonary resistance (Rint) between T0 and T120 Baseline, 120 minutes after drug administration
- Secondary Outcome Measures
Name Time Method Assessment of wheezing on a 4-point scale Up to 120 minutes after drug administration Changes in respiratory rate Up to 120 minutes after drug administration Changes in measurement of pulmonary resistance Up to 120 minutes after drug administration Number of patients with adverse events Up to 17 days after last drug administration Assessment of accessory muscle recruitment on a 4-point scale Up to 120 minutes after drug administration Hospital Admission rate 120 minutes after drug administration Assessment of dyspnoea on a 4-point scale Up to 120 minutes after drug administration Changes in Oxygen Saturation (ambient air) Up to 120 minutes after drug administration Number of patients dropped out because of lack of efficacy Up to 120 minutes after drug administration Number of patients with clinical significant findings in blood pressure Up to 120 minutes after drug administration Number of patients dropped out because of adverse events Up to 17 days after last drug administration Number of patients with clinical significant findings in heart rate Up to 120 minutes after drug administration Assessment of Patient Status by investigator on a 3-question list 72 hours after drug admimistration