Effect of topical application of Nigella sativa oil and oral acetaminophen on pain in elderly with knee Osteoarthritis in Clinical Trials

Phase 1

• Conditions: Background: There is limited evidence to support the Nigella sativa' s role as an effective complementary and alternative medicine and the anti- inflammatory effects of Nigella sativa on patients with a; Elderly; Nigella sativa oil; Pain; Osteoarthritis

• Registration Number: TCTR20160125003
• Lead Sponsor: Sabzevar University Medical Sc

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2015-01-19
• Study Start: 2016-01-25
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Enrolling by invitation
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Age over 65 years, diagnosis of knee osteoarthritis according to American College Rheumatology diagnostic criteria including: 1) knee pain on most days of last month, 2) crepitus (joint sound in active motion). 3) Morning stiffness less than 30 minutes. 4) aged 45 to 60 years, 5) inflation in the examination of the knee bone, respectively (13), knee osteoarthritis confirmed by a physician, and the use of radiography, knee pain in the past 24 hours, so that the average linear measure - visual pain (VAS: Visual Analogue Score) is between 4-7 cm,

Exclusion Criteria

lack of inflammatory diseases, metabolic disorders (diabetes), cancer or malignant diseases, symptoms or a history of liver or kidney failure, treatment with oral corticosteroids in the past 4 weeks or injection in the last 6 months, no fever, lack of sensitivity and allergy Nigella sativa oil, not wanting to continue to participate in the study, supplementation with vitamin - mineral or other nutritional supplements painkillers were the exit standards of the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of topical application of Nigella sativa oil and oral 2015 Pain was determined using visual scale (VAS)

Secondary Outcome Measures

Name	Time	Method
Effect of topical application of Nigella sativa oil and oral 2015 Pain was determined using visual scale (VAS)