NCT01250236Unknown不适用
Effect of Brimonidine on Corneal Thickness
Augenarztpraxis Breisach1 个研究点 分布在 1 个国家目标入组 10 人开始时间: 2010年12月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- corneal thickness
研究概览
简要总结
Brimonidine, an alpha-2 adrenoceptor agonist, is an effective and safe medication which is widely used in glaucoma treatment. Although it is known that it is quickly taken up by the cornea following topical administration and that the cornea has alpha-2 adrenoceptors there are only few studies available on the impact brimonidine has on the cornea. The aim of the study is to find out
- whether topical administration of brimonidine results in interaction with corneal alpha-2 adrenoceptors in terms of an increase in corneal thickness and
- whether there are any differences between the response corneal epithelium, stroma and endothelium show to alpha-2 adrenoceptor stimulation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy, 18-99 years, normal ophthalmologic history, consent to participate in the study
排除标准
- •any serious medical or neurologic conditions and/or regular use of local or systemic medications
研究组 & 干预措施
verum
brimonidine 0.1% eye drops twice daily
干预措施: brimonidine 0.1% (Drug)
placebo
sodium hyaluronate 1.8mg/ml eye drops twice daily
干预措施: placebo (Drug)
结局指标
主要结局
corneal thickness
时间窗: 5 days
次要结局
- intraocular pressure(5 days)
研究者
研究点 (1)
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