THE KIMONO-STUDY.
- Conditions
- - Glomerular hyperfiltration- Solitary functioning kidney- Congenital Anomalies of the Kidney and Urinary Tract- Children- Chronic Kidney Disease- Hypertension- Proteinuria- Genetics
- Registration Number
- NL-OMON23298
- Lead Sponsor
- VU University Medical Center. Amsterdam, The Netherlands.
- Brief Summary
1. Westland R, Kurvers RAJ, Wijk JAE van, Schreuder MF. Risk factors for renal injury in children with a solitary functioning kidney. Pediatrics ePub Feb 2013<br> 2. Westland R, Schreuder MF, Bökenkamp A, Spreeuwenburg MD, Wijk JAE van. Nierschade bij kinderen met een mononier – DE KIMONO-STUDIE. Tijdschrift voor Kindergeneeskunde (6 december 2012).<br> 3. Westland R, Wijk JAE van, Schreuder MF. The reason why mother nature provided us with two kidneys: the risks of a congenital solitary functioning kidney. Nephrol Dial Transplant. 2012 Jun;27(6):2603-4. Epub 2011 Nov 5. <br> 4. Westland R, Schreuder MF, Bökenkamp A, Spreeuwenburg MD, Wijk JAE van. Renal injury in children with a solitary functioning kidney - THE KIMONO STUDY. Nephrol Dial Transplant 2011; 26: 1533-1541.<br> 5. Schreuder MF, Westland R, Wijk JAE van. Unilateral multicystic dysplastic kidney: a meta-analysis of observational studies on the incidence associated urinary tract malformations and the contralateral kidney. Nephrol Dial Transplant 2009; 24: 1810-1818.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 150
1. Patients with an congenital or acquired solitary functioning kidney;
2. Age 0 - 21 years.
1. Renal function on DMSA > 10%;
2. A solitary functioning kidney after renal transplant.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Proportion of children with signs of renal injury (hypertension, proteinuria, chronic kidney disease);<br /><br>2. Genetic malformations (CNV, SNPs).<br>
- Secondary Outcome Measures
Name Time Method 1. GFR;<br /><br>2. Blood pressure;<br /><br>3. Developmental age of renal injury;<br /><br>4. General incidence;<br /><br>5. Meta-analysis data.