Diagnostic values of 18F-fluorodeoxyglucose uptake parameters for differentiation between rheumatoid arthritis and seronegative spondyloarthopathy
Not Applicable
- Conditions
- Arthritis
- Registration Number
- JPRN-UMIN000025071
- Lead Sponsor
- Gunma University
- Brief Summary
This manuscript of this research was published in Medicine.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 35
Inclusion Criteria
Not provided
Exclusion Criteria
Patients without arthritis
Study & Design
- Study Type
- Others,meta-analysis etc
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method This study involved patients, who had rheumatoid arthritis or seronegative arthopathy (Non-RA). The FDG PET images were taken 1 hour after injection of 18F-FDG and scanned from head to toe in arms down position using a PET-CT scanner. FDG uptake was analyzed visually in each joint using Visual Scoring System (VS) from Score 1 to Score 5 and quantified as maximum SUV (SUVmax) in a standard region of interest. A total of 12 joints were evaluated in each patient. Metabolic parameters, metabolic active volume (MAV) and total lesion glycolysis (MAV X SUVmean) was also calculated. Each sum of Visual score (total visual score), SUVmax (total SUVmax), MAV (total MAV), and total lesion glycolysis (total TLG) was calculated for each patient. Thresholds to measure MAVs and TLGs were decided by ROC analysis based on the comparison with VS and SUVmax. All the parameters were compared between RA and Non-RA group.
- Secondary Outcome Measures
Name Time Method