Multicenter prospective cohort study on the risk prediction of metachronous gastric cancer after endoscopic resection by DNA methylation markers
Not Applicable
- Conditions
- Gastric cancer
- Registration Number
- JPRN-UMIN000016864
- Lead Sponsor
- Hoshi University
- Brief Summary
Among 826 patients enrolled, 782 patients had at least one follow-up, with a median follow-up of 2.97 years. Authentic metachronous gastric cancers developed in 66 patients. The highest quartile of the miR-124a-3 methylation levelhad a significant univariate HR (95% CI) (2.17 (1.07 to 4.41); p=0.032) and a multivariate-adjusted HR (2.30(1.03 to 5.10); p=0.042) of developing authentic metachronous gastric cancers. Similar trends were seen for EMX1 and NKX6-1.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 825
Inclusion Criteria
Not provided
Exclusion Criteria
1. Patients suffering from an untreated cancer 2. Active infection (Tempereture >=38 centigrade) 3. Active gastrointestinal bleeding 4. Bleeding tendency or coagulopathy 5. Patients considered unsuitable for endoscopy
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence rate of metachronous gastric cancer
- Secondary Outcome Measures
Name Time Method