Effect of Hyaluronic Acid on the Therapy of Alveolar Osteitis

Not Applicable

• Conditions: Alveolar Osteitis
• Interventions: Device: Hyaluronic acid gel; Device: Hyaluronic acid gel + carrier

• Registration Number: NCT04853589
• Lead Sponsor: Medical University of Vienna

Brief Summary

Alveolar osteitis (AO; syn. dry socket) is one of the most frequent complications following tooth removal and it is defined as presence of severe postoperative pain in and around the extraction site, which increases in severity at any time between one and three days after extraction, accompanied by a partially or completely disintegrated blood cloth within the alveolar socket, with or without halitosis, and at the same time excluding any other cause for the pain (Blum 2002). To enhance standard treatment of AO, which consists of curettage of the dry socket, rinsing with saline solution, and inducing bleeding from the exposed alveolar bone walls, numerous products have been tested. One of them is hyaluronic acid (HY). The aim of the present study is to investigate the potential effect of HY gel application in the treatment of AO. Specifically, the application of HY only (HY test group; n = 20) or the combination of HY and an absorbable collagen sponge (HY+C test group; n = 20) will be compared to standard treatment (blood clot; control group, n=20). Clinical and patient related outcome parameters will be recorded for up to 14 days after treatment. A more stable blood clot and thus improved wound healing with faster pain reduction is expected through the use of HY.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-04-16
• Study First Submitted QC: 2021-04-16
• Study First Posted: 2021-04-21
• Study Start: 2021-05-01
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-29
• Last Update Posted: 2022-09-01
• Primary Completion: 2023-05-01
• Study Completion: 2023-05-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. > 18 years;
2. Untreated AO after extraction of a permanent tooth (excluding wisdom teeth);
3. Diagnosis of AO based on the criteria of Blum (Blum 2002)

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Exclusion Criteria

4. Patients with chronic diseases and/or taking any medication, influencing hard and soft tissue healing;
5. Pregnancy;
6. History of hypersensitivity or allergy to HY;
7. Inability to attend follow-up appointments; Intake of preoperative antibiotics.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Hyaluronic acid	Hyaluronic acid gel	hyaluronic acid gel application
Hyaluronic acid+carrier	Hyaluronic acid gel + carrier	hyaluronic acid gel application together with a carrier

Primary Outcome Measures

Name	Time	Method
Pain perception by the patient	2 weeks	VAS- Visual analogue scale measured on a 10cm scale, where 0 represents no pain and 10 represents maximum pain

Trial Locations

Locations (1)

University Clinic of Dentistry, Medical University of Vienna; 🇦🇹 Vienna, Austria