In vivo and in vitro sensitivity measurements of the circadian system. Investigating individual differences.
Completed
- Conditions
- circadian rhythm disordercircadiane ritme stoornissen (slaapstoornissen), ploegendienstshift work syndrome
- Registration Number
- NL-OMON34957
- Lead Sponsor
- Rijksuniversiteit Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 18
Inclusion Criteria
healthy males between 20 and 30 years and of average chronotype
Exclusion Criteria
Symptoms of possible sleep disorder, time zone transmeridian flights (or more) one month prior to taking part in the study, Shift work during the last 3 months, Colour blindness, Visually impaired, Somatic and psychiatric diseases (no indications of depressed mood), History of chronic diseases, Excessive daily amount of caffeinated drinks, Alcohol and drug problems, Regular medication during past 3 months, Smokers, Females.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The effects of full spectrum and blue reduced light during a simulated night<br /><br>shift will be investigated for: the degree of melatonin suppression, skin<br /><br>temperature, self ratings of sleepiness, alertness, and performance. A dim<br /><br>light control will be used. The results on melatonin suppression will be<br /><br>compared within each individual for the degree of phase shift in fibroblast<br /><br>peripheral oscillators.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Prior light history will be analysed as a covariable to explain individual<br /><br>differences in response to light at night.</p><br>