Relationship Between Baseline Serum Albumin Level and Cognitive Impariment in Mild Acute Ischemic Stroke
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 435
- 试验地点
- 1
- 主要终点
- PSCI
研究概览
简要总结
This registration enrolled patients with acute ischemic stroke within 72 hours after stroke ictus. Patients was identified as first-ever stroke based on past medical histrory. Admission CT was conducted to exclude hemorrhagic stroke, but not those bleeding transformation after ischemia injury. Baseline characteristics, including demographics, vascular risk factors, lab tests and neuroimagings were collected. Patients were followed up for cognitive assessments.
详细描述
This is a perspective stroke registry cohort study. Stroke patients were included if ：(1) acute first-ever ischemic stroke and admitted within 72 hours after onset; (2) clinical stroke diagnosis was confirmed with positive diffusion-weighted magnetic resonance imaging (DW-MRI), those with isolated posterior circulations infarcts were exclude ; (3) presented with mild stroke severity ( admission NIHSS score ≤5); (4) age between 40 and 80 years.
Clinical data including demographic characteristics, risk factors, and baseline NIHSS score were assessed and collected using a standardized table by experienced neurologists. Lab tests were performed with fasting venous blood samples within 18 hours of admission.
Patients were followed up for 6 months. The cognitive functions were assessed using the Chinese version of Montreal Cognitive Assessment (MoCA).
Contributing factors to post-stroke cognitive impariment (PSCI) were determined by comparing clinical data between PSCI and non-PSCI groups. All potential confounders were introduced into the multivariate regression models.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acute first-ever ischemic stroke and admitted within 72 hours after onset;
- •clinical stroke diagnosis was confirmed with positive diffusion-weighted magnetic resonance imaging (DW-MRI), those with isolated posterior circulations infarcts were exclude ;
- •presented with mild stroke severity ( admission NIHSS score ≤5);
- •age between 40 and 80 years.
排除标准
- •Patients with index cognitive impairment or under current anti-dementia or psychiatric medication;
- •patients with large infarcts (≥1/3 middle cerebral artery territory);
- •patients with severe language or physical disability that impede neuropsychological testing;
- •patients with recurrent transient ischemic attack (TIA)/stroke during follow-up;
- •coexisting serious conditions known to impair cognitive function
结局指标
主要结局
PSCI
时间窗: 6 months post-stroke
Patients with a MoCA score of \<24 were categorized as having PSCI
次要结局
未报告次要终点
研究者
Zhu Shi
Deputy Director of Neurology
Dongguan People's Hospital