Graphene Oxide in the Surgical Management of Intrabony Periodontal Defects

Not Applicable

• Conditions: Periodontal Diseases
• Interventions: Procedure: Graphene oxide and open flap debridement; Procedure: Open flap debridement

• Registration Number: NCT05341245
• Lead Sponsor: Ain Shams University

Brief Summary

Using Graphene oxide in the surgical management of periodontal intrabony defects.

Detailed Description

Evaluation of the effect of Graphene oxide in the surgical management of periodontal intrabony defects in animals in periodontal clinical parameters with histomorphometric evaluation .

Study Timeline

• Study First Submitted: 2022-03-22
• Status Verified: 2022-04
• Study First Submitted QC: 2022-04-17
• Last Update Submitted: 2022-04-17
• Study First Posted: 2022-04-22
• Last Update Posted: 2022-04-22
• Study Start: 2022-05-01
• Primary Completion: 2023-05-01
• Study Completion: 2023-06-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 6

Inclusion Criteria

• male dogs
• 12-24 months old with approximate weight of 20-30 kg and general good health will be used

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Exclusion Criteria

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Graphene oxide group	Graphene oxide and open flap debridement	The surgical defect will be managed by open flap debridement and application of Graphene oxide
Open flap group	Open flap debridement	The surgical defect will be managed by open flap debridement

Primary Outcome Measures

Name	Time	Method
periodontal probing depth	2 months	To evaluate the use of Graphene Oxide in the surgical management of intrabony periodontal defects regarding the changes in periodontal probing depth "measured in mm " using University of North Carolina periodontal probe( UNC 15 probe ).
Clinical attachment level	2 month	To evaluate the use of Graphene Oxide in the surgical management of intrabony periodontal defects regarding the changes in clinical attachment level "measured in mm " using University of North Carolina periodontal probe( UNC 15 probe )

Secondary Outcome Measures

Name	Time	Method
Histomorphometric evaluation	2 months	To evaluate the use of Graphene Oxide in the surgical management of intrabony periodontal defects using histological sections obtained from the surgical site to do quantitative assessment of bone remodeling, modeling, and structure by "counting the number of osteoblasts and the number of bone trabeculae " using computer based microscope and software.