A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma
- Conditions
- LymphomaMultiple MyelomaAcute Myeloid LeukemiaDiffuse Large B-Cell Lymphoma
- Interventions
- Drug: Anti-CD20 Targeting agent
- Registration Number
- NCT03530683
- Lead Sponsor
- Pfizer
- Brief Summary
The purpose of this clinical trial is to learn how the experimental medicine maplirpacept (PF-07901801) affects people with various types of blood cancers:
* relapsed or refractory (R/R) lymphoma
* multiple myeloma
* newly diagnosed acute myeloid leukemia (AML).
This trial will be conducted in the outpatient setting in 2 parts, phase 1a and phase 1b. You may only participate in one part of the study.
During phase 1a of this study, we will explore how much maplirpacept (PF-07901801), when used by itself, can be safely used.
If you have lymphoma, the study medicine maplirpacept (PF-07901801) will be given by infusion through a vein once a week or once every 2 weeks or every 3 weeks as determined by your doctor. Following your first dose, you will be expected to come back twice more the first week. From week 2, you will have weekly visits for blood tests, questions about your medications, any side effects, or illnesses you may have experienced and your cancer response. After you have completed 21 days (for every week dosing) or 42 days (for every 2- or 3-weeks dosing), your doctor will discuss whether you should stop study treatment or continue.
If you continue, you will be expected to come back weekly for blood tests, vital signs, a brief physical exam, asked about any side effects or illnesses you may have experienced and medications you may be taking. The dosing schedule you are assigned to will continue until your disease has worsened, significant side effects occur or other reasons that lead you and your doctor to decide treatment may be stopped.
To be eligible for the first part of the study you must be 18 years or older, your disease has worsened after receiving other medicines approved for blood cancer, no other treatment options exist for you, a sample of your tissue for exploratory research which can be taken from tissue already obtained or if necessary, a new sample of your tissue will be taken so your disease may be seen and measured on routine tests/scans. If you have had radiation therapy or received any anticancer medication within 14 days before the planned start of study treatment your doctor will let you know if you are eligible to participate in the study. If you have had major surgery within 30 days before the planned start of study treatment you may not be eligible to participate.
The phase 1a part of the study may last up to 51/2 years. How long you participate in this study depends on side effects you may have to the study drug. It also depends on how your cancer responds to the study drug. Therefore, you may remain in the study as long as you and your study doctor think you may benefit. However, you are free to stop taking part in this study at any time and for any reason.
During phase 1b part of this study, we will explore how much maplirpacept (PF-07901801), when used with other anticancer medicine(s), can be safe and reduce cancer growth. In the phase 1b part of this study, you will receive maplirpacept (PF-07901801) and other anticancer medicine(s). Which medicine combination you will receive depends on the types of cancer under treatment. Your treatment experiences will be examined to determine if maplirpacept (PF-07901801) when given with other anticancer medicine(s), is safe and can reduce cancer growth.
To be eligible for the second part of the study you may have newly diagnosed Acute Myelocytic Leukemia with or without a genetic mutation or you have Multiple Myeloma or Diffuse Large B Cell Lymphoma, and your disease has worsened.
The Phase 1b part of this study may last as long as you and your study doctor think you may benefit which could be up to approximately 31/2 years. How long you participate in this study depends on side effects you may have to the study drug. It also depends on how your cancer responds to the study drug. Therefore, you may remain in the study as long as you and your study doctor think you may benefit. However, you are free to stop taking part in this study at any time and for any reason.
- Detailed Description
This is a trial of maplirpacept (PF-07901801) in subjects with relapsed or refractory lymphoma or multiple myeloma (MM) and subjects with newly diagnosed acute myeloid leukemia (AML).
This trial will be conducted in 2 phases: Phase 1a (Dose-Escalation Phase for Single-Agent maplirpacept (PF-07901801) and Phase 1b maplirpacept (PF-07901801) Combinations and Single-Agent.
In the Dose-Escalation Phase for Single-Agent maplirpacept (PF-07901801), subjects with relapsed or refractory lymphoma will be enrolled in sequential dose cohorts.
In the Combination and Single-Agent Treatment part, subjects will be included in 1 of 14 cohorts: (Cohort A1 and A2) subjects with newly diagnosed TP53-mutated AML will be treated with maplirpacept (PF-07901801) + azacitidine; (Cohort B1 and B2) elderly subjects or subjects unfit for intensive induction chemotherapies with newly diagnosed TP53-wildtype AML will be treated with maplirpacept (PF-07901801) + azacitidine and venetoclax; (Cohort C1, C2, and C3) subjects with relapsed or refractory MM will be treated with maplirpacept (PF-07901801) + carfilzomib and dexamethasone;(Cohort D1 and D2) subjects in relapsed or refractory CD20+ diffuse large B-cell lymphoma will be treated with maplirpacept (PF-07901801) + an anti-CD20 targeting agent; (Cohort E1 and E2) subjects with relapsed refractory MM will be treated with single-agent maplirpacept (PF-07901801); and (Cohorts F1, F2 and F3) with relapsing or refractory MM will be treated with increasing doses of maplirpacept (PF-07901801) + isatuximab, carfilzomib and dexamethasone.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 177
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description Cohort D1 and D2: maplirpacept (PF-07901801) + an anti-CD20 targeting agent Anti-CD20 Targeting agent Cohort D1: participants with Relapsing or Recurrent (R/R) CD20+ Diffuse Large B Cell Lymphoma (DLBCL) will be treated with maplirpacept (PF-07901801) QW, then an increased dose Q3W + an anti-CD20 targeting agent. Cohort D2: participants with R/R CD20+ DLBCL will be treated with maplirpacept (PF-07901801) dosed QW for 4 weeks, then an increased dose Q3W + an anti-CD20 targeting agent. maplirpacept (PF-07901801) Monotherapy Maplirpacept (PF-07901801) In the phase 1a dose- escalation part for single-agent maplirpacept (PF-07901801), participants with Relapsing or Refractory (R/R) lymphoma will be enrolled in sequential dose cohorts to receive maplirpacept (PF-07901801) QW to characterize safety, tolerability, and PK; to determine the Maximum Tolerated Dose (MTD) or P1b Starting Dose (a dose lower than or equal to the single-agent MTD), and to gain preliminary evidence of antitumor activity. In addition, participants with R/R Lymphoma may also be enrolled in a cohort to receive maplirpacept (PF-07901801) Q2W and a cohort to receive maplirpacept (PF-07901801) Q3W to characterize safety, tolerability, and PK; to determine the MTD; and to gain preliminary evidence of antitumor activity. Cohort C1, C2 and C3: maplirpacept (PF-07901801) + Carfilzomib and Dexamethasone Maplirpacept (PF-07901801) Cohort C1: participants with Relapsing or Refractory (R/R) Multiple Myeloma (MM) will be treated with maplirpacept (PF-07901801) QW + carfilzomib and dexamethasone. Cohort C2: participants with R/R MM will be treated with maplirpacept (PF-07901801) QW + carfilzomib and dexamethasone. Cohort C3: participants with R/R MM will be treated with maplirpacept (PF-07901801) Q2W + carfilzomib and dexamethasone. Cohort D1 and D2: maplirpacept (PF-07901801) + an anti-CD20 targeting agent Maplirpacept (PF-07901801) Cohort D1: participants with Relapsing or Recurrent (R/R) CD20+ Diffuse Large B Cell Lymphoma (DLBCL) will be treated with maplirpacept (PF-07901801) QW, then an increased dose Q3W + an anti-CD20 targeting agent. Cohort D2: participants with R/R CD20+ DLBCL will be treated with maplirpacept (PF-07901801) dosed QW for 4 weeks, then an increased dose Q3W + an anti-CD20 targeting agent. Cohort A: maplirpacept (PF-07901801) + Azacitidine Maplirpacept (PF-07901801) Cohort A1: participants with newly diagnosed TP53-mutated Acute Myelocytic Leukemia (AML) will be treated with maplirpacept (PF-07901801) QW + azacitidine. Cohort A2: participants with newly diagnosed TP53-mutated AML will be treated with maplirpacept (PF-07901801) QW + azacitidine. Cohort B: maplirpacept (PF-07901801) + Azacitidine and Venetoclax Maplirpacept (PF-07901801) Cohort B1: elderly or unfit participants with newly diagnosed TP53-wildtype AML will be treated with maplirpacept (PF-07901801) QW + azacitidine and venetoclax Cohort B2: elderly or unfit participants with newly diagnosed TP53-wildtype AML will be treated with maplirpacept (PF-07901801) QW + azacitidine and venetoclax. Cohort E1 and E2: single agent maplirpacept (PF-07901801) Maplirpacept (PF-07901801) Cohort E1: participants with Relapsing or Recurrent (R/R) Multiple Myeloma (MM) will be treated with single agent maplirpacept (PF-07901801) QW. Cohort E2: participants with R/R MM will be treated with single agent maplirpacept (PF-07901801) increased dose QW. Cohort F1, F2 and F3: maplirpacept (PF-07901801) + isatuximab, carfilzomib and dexamethasone Maplirpacept (PF-07901801) Cohort F1: participants with Relapsing or Recurrent (R/R) Multiple Myeloma (MM) will be treated with increasing doses of maplirpacept (PF-07901801) + isatuximab, carfilzomib and dexamethasone. Cohort F2: participants with R/R MM will be treated with maplirpacept (PF-07901801) QW + isatuximab, carfilzomib and dexamethasone. Cohort F3: participants with R/R MM will be treated with maplirpacept (PF-07901801) increased dose QW + isatuximab, carfilzomib and dexamethasone. Cohort A: maplirpacept (PF-07901801) + Azacitidine Azacitidine Cohort A1: participants with newly diagnosed TP53-mutated Acute Myelocytic Leukemia (AML) will be treated with maplirpacept (PF-07901801) QW + azacitidine. Cohort A2: participants with newly diagnosed TP53-mutated AML will be treated with maplirpacept (PF-07901801) QW + azacitidine. Cohort B: maplirpacept (PF-07901801) + Azacitidine and Venetoclax Venetoclax Cohort B1: elderly or unfit participants with newly diagnosed TP53-wildtype AML will be treated with maplirpacept (PF-07901801) QW + azacitidine and venetoclax Cohort B2: elderly or unfit participants with newly diagnosed TP53-wildtype AML will be treated with maplirpacept (PF-07901801) QW + azacitidine and venetoclax. Cohort B: maplirpacept (PF-07901801) + Azacitidine and Venetoclax Azacitidine Cohort B1: elderly or unfit participants with newly diagnosed TP53-wildtype AML will be treated with maplirpacept (PF-07901801) QW + azacitidine and venetoclax Cohort B2: elderly or unfit participants with newly diagnosed TP53-wildtype AML will be treated with maplirpacept (PF-07901801) QW + azacitidine and venetoclax. Cohort F1, F2 and F3: maplirpacept (PF-07901801) + isatuximab, carfilzomib and dexamethasone Carfilzomib Cohort F1: participants with Relapsing or Recurrent (R/R) Multiple Myeloma (MM) will be treated with increasing doses of maplirpacept (PF-07901801) + isatuximab, carfilzomib and dexamethasone. Cohort F2: participants with R/R MM will be treated with maplirpacept (PF-07901801) QW + isatuximab, carfilzomib and dexamethasone. Cohort F3: participants with R/R MM will be treated with maplirpacept (PF-07901801) increased dose QW + isatuximab, carfilzomib and dexamethasone. Cohort F1, F2 and F3: maplirpacept (PF-07901801) + isatuximab, carfilzomib and dexamethasone Dexamethasone Cohort F1: participants with Relapsing or Recurrent (R/R) Multiple Myeloma (MM) will be treated with increasing doses of maplirpacept (PF-07901801) + isatuximab, carfilzomib and dexamethasone. Cohort F2: participants with R/R MM will be treated with maplirpacept (PF-07901801) QW + isatuximab, carfilzomib and dexamethasone. Cohort F3: participants with R/R MM will be treated with maplirpacept (PF-07901801) increased dose QW + isatuximab, carfilzomib and dexamethasone. Cohort F1, F2 and F3: maplirpacept (PF-07901801) + isatuximab, carfilzomib and dexamethasone Isatuximab Cohort F1: participants with Relapsing or Recurrent (R/R) Multiple Myeloma (MM) will be treated with increasing doses of maplirpacept (PF-07901801) + isatuximab, carfilzomib and dexamethasone. Cohort F2: participants with R/R MM will be treated with maplirpacept (PF-07901801) QW + isatuximab, carfilzomib and dexamethasone. Cohort F3: participants with R/R MM will be treated with maplirpacept (PF-07901801) increased dose QW + isatuximab, carfilzomib and dexamethasone. Cohort C1, C2 and C3: maplirpacept (PF-07901801) + Carfilzomib and Dexamethasone Carfilzomib Cohort C1: participants with Relapsing or Refractory (R/R) Multiple Myeloma (MM) will be treated with maplirpacept (PF-07901801) QW + carfilzomib and dexamethasone. Cohort C2: participants with R/R MM will be treated with maplirpacept (PF-07901801) QW + carfilzomib and dexamethasone. Cohort C3: participants with R/R MM will be treated with maplirpacept (PF-07901801) Q2W + carfilzomib and dexamethasone. Cohort C1, C2 and C3: maplirpacept (PF-07901801) + Carfilzomib and Dexamethasone Dexamethasone Cohort C1: participants with Relapsing or Refractory (R/R) Multiple Myeloma (MM) will be treated with maplirpacept (PF-07901801) QW + carfilzomib and dexamethasone. Cohort C2: participants with R/R MM will be treated with maplirpacept (PF-07901801) QW + carfilzomib and dexamethasone. Cohort C3: participants with R/R MM will be treated with maplirpacept (PF-07901801) Q2W + carfilzomib and dexamethasone.
- Primary Outcome Measures
Name Time Method Phase 1a: Number of adverse events (AE) by severity Through study completion, up to 18 months To characterize the safety profile (incidence of AEs)
Phase 1a: Number of AEs by Frequency Through study completion, up to 18 months To characterize the safety profile (incidence of AEs) and
Phase 1a: Number of participants with Dose-Limiting Toxicities (DLT) Up to 21-42 days To characterize the dose limiting toxicities (DLTs) of TTI-622.
Phase 1b: Number of adverse events (AE) by severity Through study completion, up to 30 months To characterize the safety profile (incidence of AEs) of TTI-622 given in combinations or as a single agent.
Phase 1b: Number of adverse events (AE) by frequency Through study completion, up to 30 months To characterize the safety profile (incidence of AEs) of TTI-622 given in combination or as a single agent.
Phase 1b: Number of participants with disease response Through study completion, up to 30 months To evaluate response rate of each combination treatment in the (7) combination cohorts (A1,A2, B1, B2, C1, C2, C3, D1, D2, F1, F2, F3) and for single agent treatment (Cohort E1 and E2). For AML, response = CR. For MM, response = CR+sCR+VGBR+PR. For DLBCL, OR=CR+PR
Phase 1a: Maximum Tolerated Dose (MTD) Baseline (the start of each sequentially increased treatment dose), up to the 3rd evaluable patient completes DLT observation period of 21 or 42 days. To characterize the highest dose level for which no more than 1 participant in a dose cohort experienced DLTs.
Phase 1b: Recommended dose of TTI-622 in combination with selected anticancer treatments Through study completion, up to 30 months To characterize the recommended dose of TTI-622 in combination with selected anticancer treatments in 5 patient populations:
* TTI-622 plus azacitidine in newly diagnosed TP53-mutated AML
* TTI-622 plus azacitidine and venetoclax in elderly (\>/= 75 years old) or unfit, newly diagnosed TP53-wildtype AML
* TTI-622 plus Carfilzomib and dexamethasone in Carfilzomib-refractory, Relapsed/Refractory (R/R) multiple myeloma (MM) after 3 or more prior lines of therapy
* TTI-622 plus an anti-CD20 targeting agent (such as ruxience or rituxan) in R/R CD20+ DLBCL after 1 or more prior lines of therapy
* TTI-622 plus isatuximab, carfilzomib and dexamethasone in R/R MM after 1-3 prior lines of therapyPhase 1b: Recommended dose of TTI-622 as a single agent Through study completion, up to 30 months To characterize the recommended dose of TTI-622 as a single agent in patients with R/R MM after 3 or more prior lines of therapy.
Number of participants with response assessments that show preliminary efficacy Through study completion, up to 30 months To evaluate preliminary efficacy of each combination treatment in the selected patient populations and for single-agent treatment in R/R MM
- Secondary Outcome Measures
Name Time Method Phase 1a: Number of participants with disease control rate (DCR) Through study completion, up to 18 months To determine the disease control rate (DCR) for participants treated with TTI-622.
Phase 1a: TTI-622 PK parameter AUC0-t Through study completion, up to 18 months To characterize AUC0-t of TTI-622.
Phase 1a: TTI-622 PK parameter Cmax Through study completion, up to 18 months To characterize Cmax of TTI-622.
Phase 1a: Incidence of anti-drug antibodies (ADA) Through study completion, up to 18 months To characterize the immunogenicity of TTI-622.
Phase 1a: Number of participants with overall response rate (ORR) for participants treated with TTI-622. Through study completion, up to 18 months To determine the disease response.
Phase 1a: Time to response (TTR) Through study completion, up to 18 months To determine the time to response (TTR) for participants treated with TTI-622.
Phase 1a: Duration of Response (DR) Through study completion, up to 18 months To determine the duration of response (DR) for participants treated with TTI-622.
Phase 1a: Progression free survival (PFS) Through study completion, up to 18 months To determine the progression free survival (PFS) time for participants treated with TTI-622.
Phase 1b: TTI-622 PK parameter Cmax when combined with selected anticancer treatments or as a single agent Through study completion, up to 30 months To characterize Cmax of TTI-622 when combined with selected anticancer treatments or as a single agent.
Phase 1b: incidence of anti-drug antibodies (ADA) Immunogenicity of TTI-622 when combined with selected anticancer treatments or as a single agent Through study completion, up to 30 months To characterize the immunogenicity of TTI-622 when combined with selected anticancer treatments or as a single agent
Phase 1b: Number of participants with disease control rate (DCR) Through study completion, up to 30 months To determine the disease control rate (DCR) for participants treated with TTI-622 when combined with selected anticancer treatments or as a single agent.
Phase 1b: Time to response (TTR) Through study completion, up to 30 months To determine the time to response (TTR) for participants treated with TTI-622 when combined with selected anticancer treatments or as a single agent.
Phase 1b: Event-free survival (EFS) Through study completion, up to 30 months To determine event-free survival (EFS; for Cohorts A and B) time for participants treated with TTI-622 when combined with selected anticancer treatments or as a single agent.
Phase 1b: Duration of response (DR) Through study completion, up to 30 months To determine the duration of response (DOR) for participants treated with TTI-622 when combined with selected anticancer treatments or as a single agent.
Phase 1b: Progression-free survival (PFS) Through study completion, up to 30 months To determine the progression-free survival (PFS) time for participants treated with TTI-622 when combined with selected anticancer treatments or as a single agent.
Phase 1b: Number of Participants With Minimal Residual Disease Burden (MRD) Positive, Negative and Not Evaluable (NE) Status Through study completion, up to 30 months To determine minimal residual disease (MRD; for Cohorts A, B, C , E and F) for participants treated with TTI-622 when combined with selected anticancer treatments or as a single agent.
Trial Locations
- Locations (61)
LAC+USC Medical Center
🇺🇸Los Angeles, California, United States
USC/Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
Northside Hospital
🇺🇸Atlanta, Georgia, United States
Thomas Jefferson University, Investigational Drug Service
🇺🇸Philadelphia, Pennsylvania, United States
Swedish Cancer Institute
🇺🇸Seattle, Washington, United States
Swedish Medical Center
🇺🇸Seattle, Washington, United States
Novant Health Presbyterian Medical Center
🇺🇸Charlotte, North Carolina, United States
Summit Medical Group Cancer Center
🇺🇸Florham Park, New Jersey, United States
Memorial Sloan Kettering Cancer Center at Westchester
🇺🇸Harrison, New York, United States
Prisma Health-Upstate Cancer Institute
🇺🇸Greenville, South Carolina, United States
Thomas Jefferson University Investigational Drug Services
🇺🇸Philadelphia, Pennsylvania, United States
Memorial Sloan Kettering Cancer Center at Commack
🇺🇸Commack, New York, United States
Memorial Sloan Kettering Bergen
🇺🇸Montvale, New Jersey, United States
Memorial Sloan Kettering Cancer Center at Basking Ridge
🇺🇸Basking Ridge, New Jersey, United States
HealthONE Presbyterian/St. Luke's Medical Center
🇺🇸Denver, Colorado, United States
Tampa General Hospital Cancer Institute
🇺🇸Tampa, Florida, United States
Tampa General Hospital
🇺🇸Tampa, Florida, United States
Indiana Blood & Marrow Transplantation
🇺🇸Indianapolis, Indiana, United States
Barbara Ann Karmanos Cancer Institute
🇺🇸Detroit, Michigan, United States
Keck Hospital of USC
🇺🇸Los Angeles, California, United States
Colorado Blood Cancer Institute
🇺🇸Denver, Colorado, United States
Keck Hospital of USC Pasadena
🇺🇸Pasadena, California, United States
Medical Oncology Hematology Consultants, PA, Helen F. Graham Cancer Center
🇺🇸Newark, Delaware, United States
Christiana Care Hematology Oncology - Helen F Graham Cancer Center
🇺🇸Newark, Delaware, United States
Christiana Care Health Services - Christiana Hospital
🇺🇸Newark, Delaware, United States
Blood and Marrow Transplant Group of Georgia
🇺🇸Atlanta, Georgia, United States
Georgetown University Medical Center
🇺🇸Washington, District of Columbia, United States
Indiana Blood and Marrow Transplantation-Administrative Offices
🇺🇸Indianapolis, Indiana, United States
Indiana Blood and Marrow Transplantation-Clinic
🇺🇸Indianapolis, Indiana, United States
Karmanos Cancer Institute Weisberg Cancer Treatment Center
🇺🇸Farmington Hills, Michigan, United States
Memorial Sloan Kettering Cancer Center at Monmouth
🇺🇸Middletown, New Jersey, United States
Memorial Sloan Kettering Cancer Center at Montvale
🇺🇸Montvale, New Jersey, United States
Roswell Park Cancer Institute
🇺🇸Buffalo, New York, United States
Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy
🇺🇸Long Island City, New York, United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center
🇺🇸New York, New York, United States
Memorial Sloan Kettering Cancer Center at Nassau
🇺🇸Uniondale, New York, United States
Memorial Sloan Kettering Cancer Center (Outpatient Center)
🇺🇸New York, New York, United States
Memorial Sloan Kettering Cancer Center
🇺🇸New York, New York, United States
Novant Health Cancer Institute Hematology - Charlotte
🇺🇸Charlotte, North Carolina, United States
Thomas Jefferson University - Clinical Research Institute
🇺🇸Philadelphia, Pennsylvania, United States
Sidney Kimmel Cancer Center, Clinical Trials Organization
🇺🇸Philadelphia, Pennsylvania, United States
Sidney Kimmel Cancer Center, Research Support Services
🇺🇸Philadelphia, Pennsylvania, United States
Thomas Jefferson University, Medical Oncology
🇺🇸Philadelphia, Pennsylvania, United States
West Penn Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
University of TN Medical Center
🇺🇸Knoxville, Tennessee, United States
The University of Texas MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
Oncology Consultants P.A.
🇺🇸Houston, Texas, United States
Christiana Care Health Services
🇺🇸Newark, Delaware, United States
Gabrail Cancer Center Research
🇺🇸Canton, Ohio, United States
Prisma Health, Institute for Translational Oncology Research, Clinical Research Unit
🇺🇸Greenville, South Carolina, United States
Norton Cancer Institute, St Matthews Campus
🇺🇸Louisville, Kentucky, United States
University of Michigan Hospitals
🇺🇸Ann Arbor, Michigan, United States
University of Michigan
🇺🇸Ann Arbor, Michigan, United States
Novant Health Cancer Institute Hematology - Forsyth
🇺🇸Winston-Salem, North Carolina, United States
Norton Cancer Institute, St. Matthews Campus, Attn. Becky Champion, PharmD
🇺🇸Louisville, Kentucky, United States
Norton Women & Children's Hospital
🇺🇸Louisville, Kentucky, United States
Norton Diagnostic Center-Dupont (PET Scans)
🇺🇸Louisville, Kentucky, United States
Novant Health Cancer Institute - Research Office
🇺🇸Winston-Salem, North Carolina, United States
Novant Health Forsyth Medical Center
🇺🇸Winston-Salem, North Carolina, United States
Montefiore Medical Center
🇺🇸Bronx, New York, United States
Thomas Jefferson University
🇺🇸Philadelphia, Pennsylvania, United States