Driving Pressure Limited Ventilation Decreases Postoperative Pulmonary Complications in One-Lung Ventilation: Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 312
- 试验地点
- 2
- 主要终点
- The incidence of postoperative pulmonary complications
研究概览
简要总结
This study aims to prove that driving pressure limited ventilation is superior in preventing postoperative pulmonary complications to existing protective ventilation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults greater than or equal to 19 years
- •Patient who undergoes one-lung ventilation for thoracic surgery
排除标准
- •The American Society of Anesthesiologists (ASA) Physical Status classification greater than or equal to 4
- •Patient who is contraindicated with application of positive end expiratory pressure
- •Patient who rejects being enrolled in the study
研究组 & 干预措施
Protective Ventilation
The control arm receives existing conventional protective ventilation with tidal volume of 6mL/kg of ideal body weight and positive end expiratory ventilation of 5cmH2O during one-lung ventilation
Driving Pressure Limited Ventilation
The intervention arm receives driving pressure limited ventilation during one-lung ventilation
干预措施: Driving Pressure Limited Ventilation (Other)
结局指标
主要结局
The incidence of postoperative pulmonary complications
时间窗: within the first 3 days after surgery
Patient is regarded to have postoperative pulmonary complication when 4 or more positive variables exists according to Melbourne Group Scale.
次要结局
- The ratio of partial pressure arterial oxygen and fraction of inspired oxygen(on the first postoperative day)
- Partial pressure of oxygen in arterial blood(during surgery)
研究者
Hyun Joo Ahn
Associate Professor
Samsung Medical Center