Driving Pressure and Postoperative Pulmonary Complications

Not Applicable

Completed

• Conditions: One-Lung Ventilation; Postoperative Respiratory Complications; Driving Pressure
• Interventions: Other: Driving Pressure Limited Ventilation

• Registration Number: NCT02851238
• Lead Sponsor: Samsung Medical Center

Brief Summary

This study aims to prove that driving pressure limited ventilation is superior in preventing postoperative pulmonary complications to existing protective ventilation.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2016-07-28
• Study First Submitted QC: 2016-07-29
• Study First Posted: 2016-08-01
• Study Start: 2016-08-12
• Primary Completion: 2017-08-31
• Study Completion: 2017-09-01
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-04
• Last Update Posted: 2018-10-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 312

Inclusion Criteria

• Adults greater than or equal to 19 years
• Patient who undergoes one-lung ventilation for thoracic surgery

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Exclusion Criteria

• The American Society of Anesthesiologists (ASA) Physical Status classification greater than or equal to 4
• Patient who is contraindicated with application of positive end expiratory pressure
• Patient who rejects being enrolled in the study

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Driving Pressure Limited Ventilation	Driving Pressure Limited Ventilation	The intervention arm receives driving pressure limited ventilation during one-lung ventilation

Primary Outcome Measures

Name	Time	Method
The incidence of postoperative pulmonary complications	within the first 3 days after surgery	Patient is regarded to have postoperative pulmonary complication when 4 or more positive variables exists according to Melbourne Group Scale.

Secondary Outcome Measures

Name	Time	Method
The ratio of partial pressure arterial oxygen and fraction of inspired oxygen	on the first postoperative day	The ratio will be obtained from the first arterial blood gas analysis on the first postoperative day.
Partial pressure of oxygen in arterial blood	during surgery

Trial Locations

Locations (1)

Samsung medical center; 🇰🇷 Seoul, Korea, Republic of