Transcutaneous Auricular Vagus Nerve Stimulation Improves Inhibitory Control in Emotional Go-Nogo Task
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- University of Electronic Science and Technology of China
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- The ability of inhibitory control in an emotional Go-Nogo task
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The main aim of the study is to investigate whether the transcutaneous vagus nerve stimulation(tVNS) improves the ability of inhibitory control in an emotional Go-Nogo task.
Detailed Description
A randomized, sham-controlled, between-subject design will be employed in this study. A total of 87 healthy subjects will receive either transcutaneous vagus nerve stimulation via tragus or sham stimulation via the earlobe in the left ear. Brain activity and behavioral data for an emotional Go-Nogo task will be recorded and saliva samples will be collected before, during, and after stimulation. Some personal traits will be assessed using different kinds of questionnaires, such as the State-Trait Anxiety Inventory (STAI), Beck's Depression Inventory(BDI), Autism Spectrum Quotient (ASQ) et al.
Investigators
Keith Kendrick
Professor
University of Electronic Science and Technology of China
Eligibility Criteria
Inclusion Criteria
- •Healthy subjects without past or current psychiatric or neurological disorders
Exclusion Criteria
- •history of head injury;
- •pregnant, menstruating, taking oral contraceptives;
- •medical or psychiatric illness.
Outcomes
Primary Outcomes
The ability of inhibitory control in an emotional Go-Nogo task
Time Frame: After 30 minutes stimulation
Analysis the behavioral and brain data recorded during the task
Oxytocin release
Time Frame: within 5 minutes after taVNS via tragus and earlobe
Investigating the oxytocin release after taVNS via tragus and earlobe based on saliva samples