NCT05070234Unknown不适用
Genetic Diagnosis and the Response to Recombinant Human Growth Hormone Treatment in Small for Gestational Age Children With Short Stature
Chunxiu Gong0 个研究点目标入组 150 人开始时间: 2021年10月11日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 150
- 主要终点
- Genetic testing
研究概览
简要总结
This study is a multi-center, retrospective and non-interventional research. In this study, a total of 150 short children who were small for gestational age and had been treated with recombinant human growth hormone (rhGH) are selected for genetic testing. The aims of this study are to analyze the genetic etiology of SGA children with short stature, and to compare the efficacy and safety of rhGH treatment in subjects with different etiologies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 2 Years 至 20 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Single birth, clinical diagnosis of SGA;
- •rhGH treatment beginned before puberty (Tanner stage I), regardless of gender;
- •Before starting rhGH treatment, height was lower than -2 SDS compared with normal children of the same age and sex;
- •All the subjects and their guardians signed the informed consent and the informed consent for genetic testing.
排除标准
- •No efficacy and safety data were recorded after treatment with rhGH;
- •A history of blood transfusion within 3 months before the collection of the genetic blood samples, or a history of bone marrow transplantation between rhGH treatment and the enrollment in this study;
- •Other conditions that the investigator considered unsuitable for inclusion in this study.
结局指标
主要结局
Genetic testing
时间窗: At baseline
To detect the disease-causing genes of SGA children with short stature
次要结局
未报告次要终点
研究者
Chunxiu Gong
Department of Endocrinology, Genetics and Metabolism
Beijing Children's Hospital
相似试验
招募中
不适用
A Real-world Study of the Efficacy and Safety of ICIs as First-line Therapy for Advanced MalignanciesMalignant TumorImmunotherapyArtificial IntelligenceNCT05862259Xinqiao Hospital of Chongqing120
Unknown
不适用
Genetic Predictors of Efficiency and Safety of ICIs in Patients With Different Malignancies (ICIPRESIST-0519)Squamous Cell Lung CancerUveal MelanomaMelanomaHodgkin LymphomaNCT04025424Russian Academy of Medical Sciences350
招募中
不适用
Identification of Genetic Determinants for Treatment Resistance/Sensitivity and/or Toxicity in Adjuvant Setting for HER2 Positive Breast CancerHER2-positive Breast CancerNCT04638725Centre Paul Strauss9,000
招募中
不适用
Program to Establish the Genetic and Immunologic Profile of Patient's Tumor for All Types of Advanced CancerNeoplasmsNCT01774409Centre Leon Berard10,000
Unknown
不适用
Atypical MOLes and Melanoma Early Detection Study (MoleMed)MelanomaMelanoma (Skin)MolesNevusNevus, BlueNevus, PigmentedNevus, SpitzNevi, Spindle CellNevi, DysplasticMucosal MelanosisMucosal MelanomaDysplastic Nevus SyndromeNCT04353050Russian Academy of Medical Sciences350