Randomized control trial to study the effect of yoga on neurological function, Quality of life, Biomarker and Imaging of ALS patients.

Amyotrophic lateral Sclerosis is a neurodegenerative disease of motor neurons and has poor therapeutic options with relentless progressive clinical course with severe disability and eventually mortality. Iyenger Yoga has been shown to have some effect on cramps in these group of patients. Preliminary data from our ALS registry patients have shown that few patients who are advised for Yoga and meditation do relatively well with motor, quality of life scales and cramps and fasciculations. This present trial would have a detailed and extensive study, to assess the effect of Yoga in ALS patients on neurological functions, quality of life, imaging and studied biomarker. ALS patients would be randomized by computer generated method to group patients into yoga and non-yoga group and would be assessed to compare the outcome at regular intervals of 0 and 6 months.Neurofilament light chain from serum of  yoga and control group patients along with their DTI brain sequences will be evaluated at 0 and 06 months time interval. The results would be independently assessed by an blinded assessor at the end of the study.