Clonidine als toevoeging voor de verlenging van pijnbestrijding bij oogoperaties.

Completed

• Conditions: Anaesthesia for patients scheduled for retinal cryocoagulation and episcleral explant, or cryocoagulation of ciliary body.

• Registration Number: NL-OMON25087
• Lead Sponsor: Oogziekenhuis Rotterdam (OZR)Postbus 700303000 LM, Rotterdam

Brief Summary

Górniak M, Proost JH, Veckeneer M, Mulder VC, Wubbels RJ. Clonidine as an adjuvant to prolong local analgesia in conventional scleral buckle surgery. J Ocul Pharmacol Ther. 2014; Sep 4 [Epub ahead of print]. PubMed PMID: 25188774

Detailed Description

Not available

Study Timeline

• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 108

Inclusion Criteria

1. Age ≥ 18 years;

2. Informed consent;

Exclusion Criteria

1. Hypersensitivity to clonidine or any other ingredients in the product;

2. Severe bradyarrhythmia as a result of sick sinus syndrome or 2nd or 3rd degree AV block;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Maximal pain level (VAS-score);<br /><br>2. Time of maximal post-operative pain;<br /><br>3. Amount of escape medication used;<br /><br>4. Time of use.

Secondary Outcome Measures

Name	Time	Method
1. Pharmacokinetics of clonidine will be investigated in 4 men and 4 women;<br /><br>2. Serum level of clonidine (LC-MS/MS) at 30, 60, 90 and 240 minutes after retrobulbar injection, and at postoperative day. Detection limit will be at least 0.1 µg/l.