Artificial Shrinkage of Fresh Blastocyst: Impact on Success Rates in Assisted Reproductive Technology
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 2
- 主要终点
- Clinical pregnancy rate embryo transfer
研究概览
简要总结
The aim of the study is to determine if collapsing an embryo (or making it fold compactly by taking away its fluid) before the transfer in the uterine cavity improves pregnancy rates in assisted reproductive technology (ART).
Women coming to our ART center will be randomized in two groups : the collapsing group and a control group.
Pregnancy rates will be compared in the two groups. A biomarker (cell free DNA) will also be determined in each group and correlated to pregnancy occurrence.
详细描述
This is a prospective randomized study designed to determine if artificial shrinkage (AS) before transfer of embryos impact clinical pregnancy rate in single blastocyst embryo transfer (SBET) cycle. Women elected for SBET will be randomized on transfer day in two arms:the AS group where blastocoelic cavity is artificially reduced by a laser pulse prior to transfer and a control group.
Clinical pregnancy rates will be compared. Secondarily, rate of monozygotic twin pregnancy and cell free DNA concentration in culture medium will be evaluated in the two groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 43 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Couple eligible for a transfer of a single embryo at the blastocyst stage
- •Available couple for a follow up of 12 months
排除标准
- •Attempt with frozen embryo or frozen oocyte
- •Attempt with a pre-implantation diagnosis
- •Patient has not signed informed consent
- •Couple in a period of exclusion determined by a previous study
- •Couple under legal protection, guardianship or guardianship
结局指标
主要结局
Clinical pregnancy rate embryo transfer
时间窗: 5 weeks
Clinical pregnancy rate by transfer evaluate by the visualization of at least one gestational sac with fetal heart activity during pelvic ultrasound confirmed by a positive result of the quantitative βHCG blood test.
次要结局
- Twin pregnancy rate by transfer(5 weeks)
- Free DNA level(Baseline)