Comparison of Heated humidified High-flow Nasal Cannula Flow Rates (1-L/kg/Min vs 2-L/kg/Min) in the Management of Severe Bronchiolitis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Non-invasive Ventilation
- Sponsor
- Ali Yurtseven
- Enrollment
- 168
- Locations
- 1
- Primary Endpoint
- Treatment failure rate
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Objective: The investigators aimed to compare the heated humidified high-flow nasal cannula (HHHFNC) flow rate of 1-L/kg/min (1L) with 2-L/kg/min (2L) in patients with severe bronchiolitis presenting to the pediatric emergency department.
Study design: The investigators performed a study in which all patients were allocated to receive these two flow rates. The primary outcome was admitted as treatment failure, which was defined as a clinical escalation in respiratory status. Secondary outcomes covered a decrease of respiratory rate (RR), heart rate (HR), the clinical respiratory score (CRS), rise of peripheral capillary oxygen saturation (SpO2) and rates of weaning, intubation and intensive care unit (ICU) admission.
Keywords: Bronchiolitis, Emergency department, High-flow nasal cannula, Flow rate
Investigators
Ali Yurtseven
Principal Investigator
Ege University
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of severe bronchiolitis
- •Must be less than 24 months
- •Must have presented to the emergency department
Exclusion Criteria
- •Immediate invasive ventilation and/or intensive care unit admission
- •Congenital heart disease,
- •Chronic lung disease
- •Neuromuscular disease
- •Netabolic disease
- •Craniofacial anomalies
- •Immunocompromised
- •Bacterial pneumonia
- •Pneumothorax
- •Nasal trauma
Outcomes
Primary Outcomes
Treatment failure rate
Time Frame: Within 24 hours
We compared the treatment failure between the 1-L/kg/min flow rate with 2-L/kg/min rate in patients with severe bronchiolitis