High-flow Nasal Cannula Flow Rates, Severe Bronchiolitis

Completed

• Conditions: Non-invasive Ventilation; Pediatric Pulmonary Disease
• Interventions: Device: Heated humidified high-flow nasal cannula

• Registration Number: NCT03859947
• Lead Sponsor: Ali Yurtseven

Brief Summary

Objective: The investigators aimed to compare the heated humidified high-flow nasal cannula (HHHFNC) flow rate of 1-L/kg/min (1L) with 2-L/kg/min (2L) in patients with severe bronchiolitis presenting to the pediatric emergency department.

Study design: The investigators performed a study in which all patients were allocated to receive these two flow rates. The primary outcome was admitted as treatment failure, which was defined as a clinical escalation in respiratory status. Secondary outcomes covered a decrease of respiratory rate (RR), heart rate (HR), the clinical respiratory score (CRS), rise of peripheral capillary oxygen saturation (SpO2) and rates of weaning, intubation and intensive care unit (ICU) admission.

Keywords: Bronchiolitis, Emergency department, High-flow nasal cannula, Flow rate

Detailed Description

Not available

Study Timeline

• Study Start: 2017-05-10
• Primary Completion: 2018-10-31
• Study Completion: 2018-10-31
• Status Verified: 2019-02
• Study First Submitted: 2019-02-25
• Study First Submitted QC: 2019-02-27
• Last Update Submitted: 2019-02-27
• Study First Posted: 2019-03-01
• Last Update Posted: 2019-03-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 168

Inclusion Criteria

• Clinical diagnosis of severe bronchiolitis
• Must be less than 24 months
• Must have presented to the emergency department

Exclusion Criteria

• Immediate invasive ventilation and/or intensive care unit admission
• Congenital heart disease,
• Chronic lung disease
• Neuromuscular disease
• Netabolic disease
• Craniofacial anomalies
• Immunocompromised
• Bacterial pneumonia
• Pneumothorax
• Nasal trauma

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with acute bronchiolitis	Heated humidified high-flow nasal cannula	-

Primary Outcome Measures

Name	Time	Method
Treatment failure rate	Within 24 hours	We compared the treatment failure between the 1-L/kg/min flow rate with 2-L/kg/min rate in patients with severe bronchiolitis

Trial Locations

Locations (1)

Ege University School of Medicine, Pediatric Emergency Department; 🇹🇷 İzmir, Turkey