Comparison of Heated humidified High-flow Nasal Cannula Flow Rates (1-L/kg/Min vs 2-L/kg/Min) in the Management of Severe Bronchiolitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 168
- 试验地点
- 1
- 主要终点
- Treatment failure rate
研究概览
简要总结
Objective: The investigators aimed to compare the heated humidified high-flow nasal cannula (HHHFNC) flow rate of 1-L/kg/min (1L) with 2-L/kg/min (2L) in patients with severe bronchiolitis presenting to the pediatric emergency department.
Study design: The investigators performed a study in which all patients were allocated to receive these two flow rates. The primary outcome was admitted as treatment failure, which was defined as a clinical escalation in respiratory status. Secondary outcomes covered a decrease of respiratory rate (RR), heart rate (HR), the clinical respiratory score (CRS), rise of peripheral capillary oxygen saturation (SpO2) and rates of weaning, intubation and intensive care unit (ICU) admission.
Keywords: Bronchiolitis, Emergency department, High-flow nasal cannula, Flow rate
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Day 至 2 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of severe bronchiolitis
- •Must be less than 24 months
- •Must have presented to the emergency department
排除标准
- •Immediate invasive ventilation and/or intensive care unit admission
- •Congenital heart disease,
- •Chronic lung disease
- •Neuromuscular disease
- •Netabolic disease
- •Craniofacial anomalies
- •Immunocompromised
- •Bacterial pneumonia
- •Pneumothorax
- •Nasal trauma
结局指标
主要结局
Treatment failure rate
时间窗: Within 24 hours
We compared the treatment failure between the 1-L/kg/min flow rate with 2-L/kg/min rate in patients with severe bronchiolitis
次要结局
未报告次要终点
研究者
Ali Yurtseven
Principal Investigator
Ege University