Study of epigenetic control mechanism on skeletal muscle metabolism with total knee arthroplasty.

Not Applicable

• Conditions: Osteoarthritis of the knee

• Registration Number: JPRN-UMIN000026872
• Lead Sponsor: Kansai Medical University Hospital Health science center

Brief Summary

Body weight (P=0.046), total weight (P=0.027), and total fat mass (P=0.028) were significantly lower 5 months postoperatively than preoperatively. Five months post-surgery, the PDK4 gene was significantly more hypomethylated at eight sites in the CpG island, compared to pre-surgery. There was a significant correlation (r=0.88, P=0.02) between promoter region hypomethylation and weight loss. Total methylation rate and weight loss were significantly correlated (r=0.829, P=0.042).

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-04-05
• Study Completion: 2018-11-05
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 9

Inclusion Criteria

Not provided

Exclusion Criteria

Patient of Cerebrovascular paralytic Patient of the nerve paralysis Patient of the nerve paralysis The patient who it is difficult to judge participation in study for a mental disease The other reason who principal investigator has determined to be inappropriate as a research subject.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The measure of skeletal muscle relation genes DNA methylation with osteoarthritis of knee patient.

Secondary Outcome Measures

Name	Time	Method
The measure of Myokine with osteoarthritis of knee patient.