CTRI/2021/06/034001
Active, not recruiting
Phase 2
Efficacy of low dose lung radiotherapy in the management of Covid-19 patients
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
- Sponsor
- Sri Venkateswara Institute of Medical Sciences
- Status
- Active, not recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.Age 40 years or more and 2\. Patients confirmed to have COVID\-19 based on a positive RT\_PCR for SARS CoV\-2 and have been admitted to the hospital and 3\. patients with any of a. PaO2/FiO2 between 100mmHg and 300mmHg or b. Respiratory rate \>24per min or more, breathlessness or c. SpO2 \<94% on room air and 4\. Lung parenchymal involvement at baseline CT scan
Exclusion Criteria
- •1\.Pregnancy and lactating mother
- •2\.Prior thoracic radiation or chemotherapy with potential for pulmonary toxicity
- •3\.Prior or planned treatment with interleukin inhibitors or TNF\-α inhibitors
- •4\.History of collagen vascular disease
- •5\.Chronic lung diseases (Chronic obstructive lung disease, bronchial asthma), history of pulmonary tuberculosis
- •6\.Inability to lie in supine on a flat couch with oxygen supplementation for radiation planning and delivery
- •7\.Patients with PaO2/FiO2 \<100 (severe ARDS) and/or on mechanical ventilation
- •8\.Patients who are not willing to participate in the study
Outcomes
Primary Outcomes
Not specified
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