A Study on the Effectiveness of Laparoscopic Fundoplication on Extraesophageal Manifestations of Gastroesophageal Reflux Disease (GERD)
Not Applicable
Completed
- Conditions
- Extraesophageal SymptomsGastroesophageal Reflux Disease (GERD)
- Registration Number
- NCT01324986
- Lead Sponsor
- General Public Hospital Zell am See
- Brief Summary
Available data regarding the effectiveness of laparoscopic antireflux surgery on extraesophageal symptoms of gastroesophageal reflux disease (GERD) are scarce and mostly controversial. The aim of the present study was to evaluate the clinical effect of partial and total fundoplication on extraesophageal symptoms in a selected cohort of patients with GERD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- persistent or recurrent symptoms despite continuous medical treatment, at least one typical reflux symptom (heartburn/ regurgitation/dysphagia/epigastric pain) and/or at least one atypical reflux symptom (cough/ asthma/hoarseness/distortion of taste), pathologic esophageal acid exposure as documented by a reflux-related DeMeester score ≥14.7, and symptom correlation ≥50%, and/or reflux episodes >73.
Exclusion Criteria
- previous esophageal or gastric surgery, poor physical status (American Society of Anesthesiologists (ASA) scores III and IV) and pregnancy.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie laparoscopic fundoplication's impact on extraesophageal GERD symptoms?
How does laparoscopic antireflux surgery compare to proton pump inhibitors in managing extraesophageal reflux manifestations?
Are there specific biomarkers that predict response to partial versus total fundoplication in GERD patients with extraesophageal symptoms?
What are the known adverse events associated with laparoscopic fundoplication for extraesophageal GERD manifestations and their management strategies?
What combination therapies or alternative procedures show promise in treating extraesophageal symptoms of GERD compared to laparoscopic fundoplication?
Trial Locations
- Locations (1)
General Public Hospital Zell am See
🇦🇹Zell am See, Salzburg, Austria
General Public Hospital Zell am See🇦🇹Zell am See, Salzburg, Austria