Advantages of Autologous Platelet-Rich Fibrin Membrane on Growth Factor Levels and Periodontal Healing

Not Applicable

Completed

• Conditions: Chronic Periodontitis
• Interventions: Device: Platelet rich fibrine; Device: Open Flap Debridement

• Registration Number: NCT02898675
• Lead Sponsor: Ataturk University

Brief Summary

Platelet rich fibrin is a second generation platelet concentration which contains various growth factors. The aim of this study is to evaluate the clinical and biochemical efficacy of PRF in subjects of chronic periodontitis in the operation of conventional periodontal flap.

Detailed Description

PRF was developed in 2001 by Choukroun in France, it was the second generation fibrin adhesive, and was used to accelerate the soft and hard tissue healing. Many studies have shown beneficial effects of PRF on osteoconductive filler material in sinus lift operations, treatment of periodontal sulcus defect and treatment of furcation defects. Also PRF contains many growth factors. PRF accelerates periodontal regeneration through the gradually excreted growth factors and contributes to the bone regeneration. In this study, the investigators evaluated the effect of PRF on growth factors and its contribution to periodontal regeneration in subjects with chronic periodontitis.

Study Timeline

• Study Start: 2014-10
• Primary Completion: 2015-06
• Study Completion: 2016-05
• Status Verified: 2016-08
• Study First Submitted: 2016-08-24
• Study First Submitted QC: 2016-09-08
• Last Update Submitted: 2016-09-08
• Study First Posted: 2016-09-13
• Last Update Posted: 2016-09-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• Patients with CP who had pocket depth ≤ 5 mm and at least two area (grouped as Control and PRF) with horizontal bone loss after initial treatment

Exclusion Criteria

• The subjects excluded in the study had history of systemic disease, were smokers, had allergy to any drug, had need for prophylaxis of antibiotic and had taken antibiotics at least 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Platelet Rich Fibrine	Platelet rich fibrine	Platelet Rich Fibrine was applied with open flap debridement in test group.
Open Flap Debridement	Open Flap Debridement	Platelet Rich Fibrin was not applied to control groups. Only open flap debridement was applied to control groups.

Primary Outcome Measures

Name	Time	Method
Level of Growth Factor	6 weeks	Change from baseline growth factors levels of GCF at 6 weeks were measured by periopaper

Secondary Outcome Measures

Name	Time	Method
Alteration of Clinical Attachment Level	9 month	Change from baseline Clinical Attachment Levels at 9 months were measured with periodontal probe.
Alteration of Periodontal Pocket Depth	9 month	Change from baseline Pocket Depth at 9 months were measured with periodontal probe.