IRCT2015061521970N2已完成2 期
Clinical trial comparing the effects of low dose aspirin and placebo on clinical improvement of moderate to severe aspirin-sensitive asthmatic patients with chronic rhinosinusitis and nasal polyposis
Vice chancellor for research, Iran Uiversity of Medical Sciences0 个研究点目标入组 30 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 65 years（—）
- 性别
- All
入选标准
- •18 to 65 years old; clinical symptoms of chronic rhinosinusitis with nasal polyposis which confirmed by sinus CT scan; moderate to severe asthma according to the history, spirometric findings and Expert Panel Report 3 (EPR-3) guidelines; receiving the full course of standard treatments for rhinosinusitis and asthma according to the EPR-3 guidelines for 3 months before entering study
- •Exclusion criteria: presence of serious underlying disease such as bleeding disorders, gastrointestinal, rheumatologic, cancer, heart, kidney, liver and mental diseases; medical history of immediate hypersensitivity reactions to aspirin and nonsteroidal anti-inflammatory drugs; Forced Expiratory Volume in the first second (FEV1) less than 70% at the time of aspirin challenge; pregnancy; breast-feeding; the use of systemic and topical beta-blocker, angiotensin-converting enzyme inhibitor, angiotensinogen ? receptor blocker, warfarin; mastocytosis; nonadherent patients; patients with high risk jobs or lifestyle
排除标准
- 未提供
研究者
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