NCT07353658尚未招募不适用
The Effect of Intermittent Versus Continuous Enteral Feeding on Outcomes in Severe Stroke: An Exploratory Study
Xijing Hospital0 个研究点目标入组 60 人开始时间: 2026年1月5日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
研究概览
简要总结
This is a single-center, randomized, exploratory clinical trial investigating whether intermittent enteral feeding improves outcomes compared to continuous feeding in patients with severe stroke. The study will enroll 60 patients to evaluate the impact on 90-day all-cause mortality, neurological function, nutritional status, and safety. It will also explore underlying mechanisms through analysis of metabolic profiles, circadian gene expression, and gut microbiota.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years old
- •It was definitely diagnosed as acute stroke by clinical imaging.
- •Enteral nutrition program can be started within 72 hours of onset.
- •Baseline GCS≤12 or NIHSS≥11
- •There is nutritional risk (NRS 2002≥3), Wadian drinking water test≥ 3 or there is consciousnessdisorder,it is estimated that you need to receive nutritional support treatment for ≥7 days
- •Obtain informed consent
排除标准
- •Before joining the group, he had received total parenteral nutrition treatment.
- •There are contraindications to enteral nutrition.
- •Unstable vital signs
- •Dementia or severe disability before onset (mRS≥3)
- •There are concomitant diseases that will interfere with outcome evaluation and/or follow-up.
- •Participating in other interventional clinical trials.
- •Other circumstances in which the study cannot be completed.
研究者
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