A Prospective Study to Compare Early versus Late Postpartum Oral Glucose Tolerance Test Screening in Patients with Gestational Diabetes.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- Sensitivity, specificity, Positive predictive value (PPV), Negative predictive value (NPV) of early post-partum OGTT for impaired glucose tolerance and diabetes mellitus.
研究概览
简要总结
An oral glucose tolerance test (OGTT) during the delivery hospitalization may be of use in certain circumstances in which postpartum follow-up is challenging and resources could be focused on women with an abnormal screening immediately after the delivery. Insulin resistance has been shown to improve shortly after delivery, as evidenced by the decreased insulin dose requirements in women with diabetes treated with insulin. Additionally, metabolic mediators involved in the development of GDM have been shown to decline to nonpregnant levels hours after delivery. It is reasonable to investigate whether GTT can be done after the first 48 hours (2 days) while the patient is still hospitalized.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- Female
入选标准
- •Patients diagnosed with GDM and who are less than 96 hours postpartum.
排除标准
- •Pre-existing diabetes/ Overt diabetes.
- •Patients not willing for participation.
- •Not able to take three meals.
- •Patient on corticosteroids, antidepressants, diuretics, beta blockers.
- •Patients with history of gastric bypass surgery.
结局指标
主要结局
Sensitivity, specificity, Positive predictive value (PPV), Negative predictive value (NPV) of early post-partum OGTT for impaired glucose tolerance and diabetes mellitus.
时间窗: At 12 week post partum
次要结局
- Compliance for post partum follow-up
研究者
Dr Deepali Grag
All India Institute Of Medical Sciences