Changes in Adipokines and Adiposity During Puberty and Young Adulthood
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 575
- 试验地点
- 1
- 主要终点
- Presence of brown adipose tissue
研究概览
简要总结
The investigators propose to conduct a cross-sectional study of 60 participants who are 18-30 years of age to undergo research PET/CT. The purpose of this study is to investigate the relationships between Brown Adipose Tissue (BAT), the adiponectin/leptin (A/L) ratio, and components of the metabolic syndrome in young adults.
详细描述
We propose to conduct a cross-sectional study of 60 participants who are 18-30 years of age to undergo research PET/CT. The purpose of this study is to investigate the relationships between Brown Adipose Tissue (BAT), the adiponectin/leptin (A/L) ratio, and components of the metabolic syndrome in young adults. This study is part of a larger study aimed at understanding the mechanism of brown adipose tissue as a potential protective factor against metabolic dysfunction.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males and females, 18-30 years of age at enrollment, who are obese (BMI greater or equal to 30 kg/m2, weight less than 159 kg) and healthy
- •Without medications and endocrine/genetic disorders known to affect weight.
- •Participants may have insulin resistance, impaired glucose tolerance, dyslipidemia, or hypertension.
排除标准
- •Anyone who refuses participation.
- •A genetic syndrome or other endocrine disorder known to cause obesity (Prader-Willi, Cushing Syndrome, Leptin deficiency, etc.).
- •Use of the following medications: psychotropics, sulphonylurea, thiazolidinediones, insulin, glucocorticoids, anti-neoplastic agents, angiotensin receptor blocker, angiotensin-converting enzyme inhibitors.
- •Pregnancy or history of pregnancy.
- •Active infectious disease
- •History of CVD or stroke during the previous 36 months
- •Total cholesterol 300 mg/dl, triglycerides 400 mg/dl
- •Blood pressure 140/90 mmHg
- •Fasting plasma glucose 126 mg/dl.
- •Diabetes mellitus, type 1 or 2.
结局指标
主要结局
Presence of brown adipose tissue
时间窗: 2 years
次要结局
- Presence of metabolic dysfunction(2 years)
研究者
Nicole L. Mihalopoulos
Associate Professor of Pediatrics
University of Utah