Graft Portal Reperfusion Without Purging Graft Preservative Solution In Living Donor Liver Transplantation. A Prospective Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Lowest 5 Minutes Post-reperfusion Mean Arterial Blood Pressure
研究概览
简要总结
The investigators tested the impact of purging the graft contents and mesenteric blood into the systemic circulation versus washing out this volume out of the circulation in living donor liver transplantation recipients.
详细描述
All donors had right hepatectomy. On the back table, surgeons flushed liver grafts with 4 Liters of cold Custodiol solution. Patients were randomized into either purge group (Pg) (n=40) were graft fluid contents were washed out by the patient's portal vein blood (0.5ml per gram graft weight) through incompletely anastomosed hepatic vein, or No purge group (NPg) (n=40) where graft fluid contents were washed into the systemic circulation by the patient's portal blood. The primary outcome objective was the mean arterial blood pressure 5 minutes after portal declamping. Secondary objectives included hemodynamic and oxygenation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult living donor liver transplantation recipients of either sex in mansoura liver transplantation program
排除标准
- •re-transplantation
- •Previous upper abdominal operation
- •Budd Chiari syndrome
结局指标
主要结局
Lowest 5 Minutes Post-reperfusion Mean Arterial Blood Pressure
时间窗: 5 minutes post-reperfusion
The lowest of three recorded mean arterial pressure readings at 1,3 and 5 minutes after portal declamping
次要结局
- Biliary Complications (Participants)(3 months)
- Ischemia Reperfusion Injury(7 days)
- Post-operative Infectious Complications(30 days)
- 3 Months Mortality(3 Months)
研究者
Amr Mohamed Yassen
Professor of Anesthesia and Intensive Care
Mansoura University