Effect of Bilateral Transversus Thoracis Muscle Plane Block in Patients Undergoing Coronary Artery Bypass Graft Surgery.

Completed

• Conditions: Coronary Artery Disease; Pain Syndrome
• Interventions: Procedure: Ultrasound guided Bilateral Transversus Thoracis Muscle Plane block

• Registration Number: NCT04849117
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

Coronary artery bypass graft surgery is the standard surgical treatment for coronary disease. However, there is no consensus on analgesic management in patients undergoing CABG.

The aim of the study is to evualuate efficacy of bilateral transversus thoracis muscle plane (TTMP) block combined with systemic analgesia, compared to systemic analgesia only, in patients undergoing elective on-pump CABG surgery.

Our main hypothesis is that a bilateral TTMP block performed after CABG surgery could reduce morphine consumption during the first 48 hours.

The investigators conducted an age, gender and type of surgery-matched retrospective cohort study in the Montpellier University Hospital (France).

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-01
• Primary Completion: 2019-12-01
• Study Completion: 2019-12-20
• Status Verified: 2021-03
• Study First Submitted: 2021-03-23
• Study First Submitted QC: 2021-04-12
• Last Update Submitted: 2021-04-12
• Study First Posted: 2021-04-19
• Last Update Posted: 2021-04-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Bilateral TTMP block + systemic analgesia	Ultrasound guided Bilateral Transversus Thoracis Muscle Plane block	Patients received the same protocol of systemic analgesia associated with a bilateral TTMP block performed during the first four hours after ICU admission, before tracheal tube removal.

Primary Outcome Measures

Name	Time	Method
cumulative morphine consumption	postoperative day 2	cumulative morphine consumption during the first two days. cumulative morphine consumption on postoperative day 0, 1 and 2, including the morphine administered in intensive care unit, and on postoperative day 1 and 2.

Secondary Outcome Measures

Name	Time	Method
rate of Delirium	postoperative day 7	rate of Delirium
Postoperative nausea and vomiting	hospital day 7	Postoperative nausea and vomiting
rate of Pneumonia	until postoperative day 7	rate of Pneumonia
rate of Urinary retention	until postoperative day 7	rate of Urinary retention
Urinary catheter duration	day 20	Urinary catheter duration
Duration of hospitalization in ICU	day 20	Duration of hospitalization in ICU
Postoperative pain assessed	postoperative day 0, 1 and 2	Postoperative pain assessed by visual analog scale (VAS) scoring
Occurrence of prurit	postoperative day 7	Occurrence of prurit
rate of Constipation	postoperative day 7	rate of Constipation
rate of Hypotension	until postoperative day 7	rate of Hypotension
In-hospital length of stay	day 20	In-hospital length of stay
Pleural drain duration	day 20	Pleural drain duration
Occurrence of atrial fibrillation	until postoperative day 7	Occurrence of atrial fibrillation
acute kidney injury	until postoperative day 7	acute kidney injury

Trial Locations

Locations (1)

Uh Montpellier; 🇫🇷 Montpellier, France