Comparison of Sugar Load Between Normal and Functional Variants of Sucrase-isomaltase Genes in IBS
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Region Skane
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Changes from baseline of blood glucose levels
研究概览
简要总结
The investigators know that many patients with irritable bowel syndrome (IBS) have functional variants of genes coding for sucrase-isomaltase enzymes. The investigators will now examine whether these functional variants are associated with defect degradation of sucrose and associated gastrointestinal symptoms
详细描述
The investigators have in a previous study included IBS patients for treatment with a starch- and sucrose reduced diet (SSRD). The investigators found a great improvement of symptoms. The investigators gene-tested those patients, and now have the full identification of all functional variants encoding sucrase-isomaltase enzymes.
The investigators will invite patients from this previous study with normal genes and functional variants of genes. The patients will come fasting over night to the department of clinical research. The participants will ingest 75 g sugar dissolved in 0.8 dl water and flavored with lemon, to ingest during 5 minutes. After that, glucose will determined repeatedly up to 2 hours afterwards. At the same time, the participants have to assess their gastrointestinal sympotms on visual analogue scales (VAS).
The investigators will compare the raise in b-glucose and symptoms between the groups of patients, divided into gene expression.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participants of our previous clinical trial with SSRD diet (NCT03306381)
排除标准
- •Difficulties in taking blood samples
结局指标
主要结局
Changes from baseline of blood glucose levels
时间窗: From distribution repeatedly up to 2 hours
Measurement of glucose levels in blood drawn from an intravenous needle and analyzed at the Department of Clinical Chemostry
Change from baseline of gastrointestinal symptoms
时间窗: From baseline and up to 2 hours, at the same time points as blood glucose is measured
Measurment of gastrointestinal symptoms on a visual analog scale measuring symptoms, range 0-100 mm, repeatedly at the same time points as blood glucose is measured. The higher scores, the worse symptoms.
次要结局
未报告次要终点