Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery
- Conditions
- Pain, Postoperative
- Interventions
- Registration Number
- NCT05824832
- Lead Sponsor
- Loyola University
- Brief Summary
The goal of this clinical trial is to learn if there is a difference in morphine requirements in patients after upper extremity surgeries including shoulder arthroscopy. The main question it aims to answer is whether there is a difference between Interscalene brachial plexus blocks with the addition of buprenorphine, dexamethasone, and clonidine and the same block without the adjuvant.
- Detailed Description
This study will be a prospective randomized single-blinded clinical trial.
Patients undergoing shoulder arthroscopy who meet the inclusion criteria will be invited to participate in this study. A total of 120 patients will be recruited to participate.
Patients will be randomized via a 1:1 ratio to either the Interscalene block with the addition of buprenorphine, clonidine, dexamethasone group or Interscalene block alone group
The null hypothesis of this research study is that there will be no significant difference in morphine requirements between the Interscalene brachial plexus blocks with the addition of buprenorphine, dexamethasone, and clonidine and the same block without the adjuvant.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 120
- Patients ≥ 18 years old
- Patients undergoing shoulder arthroscopy
- Patients willing to participate and sign informed consent
- Severe COPD/other contraindication to general anesthesia
- Patient with a weight of less than 60 kg
- Dementia, not alert or oriented to person, place, or time
- Chronic pain patient with daily opioid use at home.
- Patient with allergy to local anesthetics
- Patient refusal
- Total shoulder arthroplasty
- Concomitant pain in different area from operative site.
- Pregnancy
- Patient with active infection on the injection sites for the blocks
- Patients unable or willing to understand or comply with the study protocol
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Interscalene block with the addition of buprenorphine, clonidine, dexamethasone Interscalene block with the addition of buprenorphine, clonidine, dexamethasone Interscalene brachial plexus blocks (ISB) is performed with a 22g x 50 mm PAJUNK SonoPlexⓇ II Facet S echogenic needle. Once adequate needle visualization is achieved within the correct anatomic position and plane, 30mL of 0.5% bupivacaine with 100 mcg clonidine, 0.3 mg buprenorphine, and 4 mg dexamethasone will be injected. Interscalene block with buprenorphine alone Interscalene block with buprenorphine alone Interscalene brachial plexus blocks (ISB) is performed with a 22g x 50 mm PAJUNK SonoPlexⓇ II Facet S echogenic needle. Once adequate needle visualization is achieved within the correct anatomic position and plane 30mL of 0.5% bupivacaine will be injected.
- Primary Outcome Measures
Name Time Method Morphine requirement post surgery 24 hours To compare the morphine equivalents administered in the first 24 hours after arrival in the recovery area between the two groups.
- Secondary Outcome Measures
Name Time Method Pain reported via a numeric rating scale (NRS) 48 hours To measure pain via a numeric rating scale (NRS) immediately after arrival to recovery area from surgery (time: 0hr), and again at 2, 24, and 48 hours.
Trial Locations
- Locations (1)
Loyola University Chicago
🇺🇸Maywood, Illinois, United States