Effect of Transcranial Random Noise Stimulation of Prefrontal Cortex on Craving Supply Subject Suffering From Obesity
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 13
- 试验地点
- 2
- 主要终点
- Effects on craving frequencies
研究概览
简要总结
Obesity is worldwide a public health problem. According to World Health Organization (WHO), overweight and obesity are the fifth death risk factor worldwide. At least 2.8 million adults die each year. Food addiction is one of the causes of obesity that may benefit from new therapeutic options.
详细描述
Transcranial random noise stimulation is a noninvasive brain stimulation technic. The modulation of the electrical activity of the right and left dorsolateral prefrontal cortex (DLPFC) by tRNS is able to act on the phenomenon of craving in other addictions. This allows us to make the assumption that tRNS stimulation could constitute a treatment for food addiction especially in obesity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Female or male between 18 and 65 years old
- •Patients suffering from obesity, with a BMI ≥
- •Food dependence score at the Yale Food addiction Scale ≥ 3
排除标准
- •Presence of a an other psychiatric diagnosis of Axis I (DSM IV);
- •Presence of addictive comorbidity other than food addiction
- •Psychotropic treatment;
- •Pregnancy or lactation;
- •Contraindication to fMRI .
结局指标
主要结局
Effects on craving frequencies
时间窗: Change from baseline after 3 months
by questionnaires scores and declarative number of food
次要结局
- change in biological markers such as lipid profile, ghrelin, leptin, prolactin(Change from baseline after 3 months)
- change in body weight(Change from baseline after 3 months)
- change in waist circumference(Change from baseline after 3 months)
- change in body mass index(Change from baseline after 3 months)