Evaluation of Uric Acid Levels in Pediatric Patients With Migraine
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- Evaluation of Uric Acid Levels in Pediatric Patients with Migraine
研究概览
简要总结
Migraine is recognized as one of the most prevalent neurological disorders. The exact pathophysiological mechanisms underlying migraine have not yet been fully elucidated. The present study aims to compare serum uric acid levels between pediatric patients with migraine and a control group. Additionally, this study seeks to explore the potential relationship between migraine attack frequency and gender differences in pediatric patients
详细描述
Migraine is recognized as one of the most prevalent neurological disorders. The exact pathophysiological mechanisms underlying migraine have not yet been fully elucidated. The present study aims to compare serum uric acid levels between pediatric patients with migraine and a control group. Additionally, this study seeks to explore the potential relationship between migraine attack frequency and gender differences in pediatric patients Patients diagnosed with migraine were included as the study group, while the control group consisted of patients who presented to the pediatric neurology clinic during the same period for neuromotor development follow-up examinations.
Migraine patients are influenced by multiple factors, including dietary habits, levels of physical activity, and various psychosocial determinants.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 6 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients diagnosed with migraine
排除标准
- •Cerebral palsy Non-migraine headache Epilepsy Multiple congenital anomalies Congenital metabolic diseases Control group
- •Inclusion Criteria:
- •Healthy children Exclusion Criteria Neuromotor developmental delay Multiple congenital anomalies Non-migraine headache Epilepsy
结局指标
主要结局
Evaluation of Uric Acid Levels in Pediatric Patients with Migraine
时间窗: 01.08.2019 and 01.03.2024
Migraine represents a significant neurological condition affecting individuals across all age groups, with a reported prevalence of 7.7% among children and adolescents. According to the widely accepted neurogenic inflammation hypothesis, sterile inflammation occurs in the dura mater surrounding the brain as a result of neuropeptide release from perivascular trigeminal nerve endings, leading to sensitization of sensory neurons .Uric acid is known to function as a potent endogenous antioxidant and free radical scavenger within the human body. It has been suggested that uric acid exerts dual effects on the central nervous system, demonstrating both neuroprotective and neurotoxic properties depending on its concentration. Although uric acid may enhance antioxidant and anti-inflammatory responses at physiological concentrations, it has been suggested that excessively elevated serum uric acid levels may contribute to increased oxidative stress and subsequent neuronal damage. The primary ou
次要结局
未报告次要终点
研究者
Aysen Orman
Mersin University
Mersin University