Optimization of fMRI for the Study of Basal Ganglia Activation in Parkinson's Disease: T2* Measurement in the Cortex and the Basal Ganglia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- The quantitative measurement of T2* in the cortex and basal ganglia using MRI, made à J0.
研究概览
简要总结
Functional magnetic resonance imaging (fMRI) is a non-invasive imaging technique assessing neuronal activations during motor or cognitive tasks. The MRI sequences used are currently optimized for the study of cortex activations, particularly concerning the echo time (TE).Very few studies are interested in optimizing the fMRI for the study of the basal ganglia, structure implicated in many neurological diseases such as Parkinson's disease. The T2 * is a tissue parameter dependent of iron content, which differs with brain structures and probably also with age and in case of neurodegenerative disease. Optimal TE s should correspond to the T2 * of studied brain structure The primary purpose is to optimize the fMRI by a quantitative measurement of the T2* in the cortex and the basal ganglia using MRI. The secondary purpose is to study the effect of age and Parkinson's disease on T2*.
详细描述
80 subjects (40 PD patients and 40 paired healthy volunteers (on sex and age)) aged 40-80 years will be included. PD patients will be recruited in the Department of Neurology of CHU of Clermont-Ferrand. Healthy volunteers will be selected in clinical trial database. This study will consist of one visit (at J0) during which subjects will undergo a MRI (a single acquisition of 40 minutes approximately). PD patients will be further questioned on their disease and will benefit from a neurological examination
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For patients :
- •Patients with idiopathic Parkinson's disease according to UKPDSBB criterias
- •Men or women aged between 40 to 80 years
- •not treated with deep brain stimulation
- •For healthy subjects
- •- Men or women aged between 40 to 80 years
排除标准
- •For patients
- •Dementia (MMS<24)
- •Contraindication to MRI.
- •Under guardianship
- •In excluding period for another study
- •For healthy subjects
- •Antecedent of neurodegenerative diseases or psychiatric diseases
- •Contraindication to MRI
- •Under guardianship
- •In excluding period for another study
结局指标
主要结局
The quantitative measurement of T2* in the cortex and basal ganglia using MRI, made à J0.
时间窗: at day 1
次要结局
未报告次要终点