Study of the Physiology of Pre-eclampsia and Vascular IUGR With Constitution of a Biological Collection

Recruiting

• Conditions: Pre-Eclampsia

• Registration Number: NCT03626233
• Lead Sponsor: Centre Hospitalier Intercommunal Creteil

Brief Summary

Preeclampsia and intrauterine growth retardation (IUGR) are serious and frequent pathologies, specific to pregnancy. They represent 70 000 new cases a year, or 9% of pregnancies and cause 50,000 premature births per year in France. The consequences in terms of morbidity and perinatal morbidity and the medical and economic costs make it an issue public health. Pre-eclampsia associates maternal hypertension with dysfunction kidney. There is no cure for pre-eclampsia or IUGR vascular during pregnancy. These pathologies invariably evolve towards a maternal and / or fetal aggravation sometimes very fast. Primary prevention and secondary education and screening for these pathologies are still insufficient. A better understanding of the pathophysiology of these placental vascular pathologies is necessary for the development of supported medical, obstetric and pediatric that will improve the state of health maternal and neonatal

Detailed Description

Not available

Study Timeline

• Study Start: 2018-08-06
• Study First Submitted: 2018-08-08
• Study First Submitted QC: 2018-08-08
• Study First Posted: 2018-08-10
• Status Verified: 2022-12
• Last Update Submitted: 2022-12-20
• Last Update Posted: 2022-12-21
• Primary Completion: 2023-08
• Study Completion: 2024-04

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 500

Inclusion Criteria

• pregnant women
• With or without vascular pathology

Exclusion Criteria

• refusal to participate
• multiple pregnancy
• major fetal malformation diagnosed during pregnancy follow-up

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
genomic analysis on placenta	day of delivery	by chromatin immunoprecipitation-sequencing (ChIP-seq)

Secondary Outcome Measures

Name	Time	Method
genomic analysis on placenta	day of delivery	by immunohistochemistry an polymerase chain-reaction
PLGF blood level	day of delivery
sFlt1 blood level	day of delivery
VEGF blood level	day of delivery
sKDR blood level	day of delivery
genomic analysis on blood	day of delivery	by ChIP-seq

Trial Locations

Locations (1)

CHi Creteil; 🇫🇷 Creteil, France