Study of the Physiology of Pre-eclampsia and Vascular IUGR With Constitution of a Biological Collection
- Conditions
- Pre-Eclampsia
- Interventions
- Other: collect of placenta, blood and urinary samples at delivery
- Registration Number
- NCT03626233
- Lead Sponsor
- Centre Hospitalier Intercommunal Creteil
- Brief Summary
Preeclampsia and intrauterine growth retardation (IUGR) are serious and frequent pathologies, specific to pregnancy. They represent 70 000 new cases a year, or 9% of pregnancies and cause 50,000 premature births per year in France. The consequences in terms of morbidity and perinatal morbidity and the medical and economic costs make it an issue public health. Pre-eclampsia associates maternal hypertension with dysfunction kidney. There is no cure for pre-eclampsia or IUGR vascular during pregnancy. These pathologies invariably evolve towards a maternal and / or fetal aggravation sometimes very fast. Primary prevention and secondary education and screening for these pathologies are still insufficient. A better understanding of the pathophysiology of these placental vascular pathologies is necessary for the development of supported medical, obstetric and pediatric that will improve the state of health maternal and neonatal
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 500
- pregnant women
- With or without vascular pathology
- refusal to participate
- multiple pregnancy
- major fetal malformation diagnosed during pregnancy follow-up
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Vascular group collect of placenta, blood and urinary samples at delivery Pregnant women with vascular pathology Control group collect of placenta, blood and urinary samples at delivery * Pregnancy without any vascular complication * Delivery before or after 37 weeks of gestation (GW) * In case of delivery after 37GW: birth by cesarean delivery
- Primary Outcome Measures
Name Time Method genomic analysis on placenta day of delivery by chromatin immunoprecipitation-sequencing (ChIP-seq)
- Secondary Outcome Measures
Name Time Method genomic analysis on placenta day of delivery by immunohistochemistry an polymerase chain-reaction
PLGF blood level day of delivery sFlt1 blood level day of delivery genomic analysis on blood day of delivery by ChIP-seq
VEGF blood level day of delivery sKDR blood level day of delivery
Trial Locations
- Locations (1)
CHi Creteil
🇫🇷Creteil, France