Efficacy of intraoperative low dose intravenous amiodarone in pharmacologic cardioversion in patients with preoperative atrial fibrillation presenting for mitral valve replacement surgery Randomized control trial

Phase 4

• Conditions: Circulatory System; Cardiology; Anaesthesia

• Registration Number: PACTR202201680255620

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-01-24
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

·       All elective isolated cases undergoing mitral valve replacement with a preoperative atrial fibrillation rhythm > 100/min as evidenced by ECG.

·       ASA physical status 2-5

·       Sex (males and females)

·       Age 18-70 years.

Exclusion Criteria

·       Patients are refusing to participate in the study.

·       Below 18 or above 60 years.

·       Emergency and urgent patients.

·       Patients are undergoing combined valve or CABG surgery.

·       Patients with previous PCI.

·       Patients with rhythm defects evidenced by ECG.

·       Patient on amiodarone or other rhythm modifying drugs, e.g., Digoxin, Beta Blockers, CCBs, etc.

·       Patients with preoperative lung conditions or O2 saturation below 90%.

·       Patients with preoperative abnormal hepatic profiles identified by double average values of ALT/AST or bilirubin or hypoalbuminemia

·       Patients with preoperative renal impairment identified by serum creatinine more than 1.7 mg/dL

·       Abnormal thyroid profile or any history suggestive of thyroid diseases.

·       Diabetic patients, as the study, include Dextrose 5% based medication.

Study & Design

• Study Type: Interventional
• Study Design: Not specified