NCT00536068已完成不适用
Platelet Inhibition by Aspirin, Acetaminophen and NSAID
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- platelet aggregation
研究概览
简要总结
Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the inhibition of platelet aggregation by aspirin, because they all interact with the platelet cyclooxygenase.This may be of great clinical importance because of an increased cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.
详细描述
An in vivo study on healthy volunteers with combinations of well established drugs
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
排除标准
- •Administration of drugs affecting platelets
- •History of bleeding
- •Gastrointestinal disorders
- •Hypersensitivity to aspirin and/or NSAID
- •Pregnancy and breast feeding
研究组 & 干预措施
1, 2, 3, 4
Experimental
- acetylsalicylic acid 100 mg/po,acetaminophen 3x1g/po
- acetylsalicylic acid 100 mg/po,diclofenac 3x50mg/po
- acetylsalicylic acid 100 mg/po,naproxen 3x250mg/po
- acetylsalicylic acid 100 mg/po,placebo 3x1/po
干预措施: Acetylsalicylic acid, acetaminophen, diclofenac, naproxen, placebo (Drug)
结局指标
主要结局
platelet aggregation
时间窗: 5 days
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
招募中
3 期
PRACTICAL TRIAACTRN12605000581662Cardiology Dept, Royal Perth Hospital370
已完成
不适用
Tranexamic Acid in Clopidogrel Exposure to Decrease Hemorrhage and TransfusionCoronary Artery DiseaseNCT01060163Chinese Academy of Medical Sciences, Fuwai Hospital552
已完成
3 期
The Effect of Drug on the Patency Rate of Fistulaechoronic renal failure.End-stage renal diseaseIRCT201009292220N3Vice-Chancellor for Research, Shahid Beheshti University of Medical Sciences501
已完成
1 期
The effect of low dose aspirin on platelet inhibition in patients with rheumatoid arthritisCondition 1: Rheumatoid arthritis. Condition 2: Rheumatoid arthritis.Rheumatoid arthritis, unspecifiedIRCT201707293812N6Connective Tissue research Center- Tabriz University of Medical Sciences45
已完成
不适用
Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation in Analgetic DosagesPlatelet AggregationNCT00763997Ruhr University of Bochum80