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Clinical Trials/NCT05843604
NCT05843604
Recruiting
Not Applicable

Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-compulsive Disorder: Towards Personalization of Patient Care

Centre Hospitalier Henri Laborit1 site in 1 country100 target enrollmentJuly 3, 2023
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ConditionsOCD

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
OCD
Sponsor
Centre Hospitalier Henri Laborit
Enrollment
100
Locations
1
Primary Endpoint
Cerebral activity modification during N-back task
Status
Recruiting
Last Updated
3 months ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.

Registry
clinicaltrials.gov
Start Date
July 3, 2023
End Date
September 1, 2027
Last Updated
3 months ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)
  • •Understand and accept the constraints of the study
  • •Be a beneficiary or affiliated to a Health Insurance scheme

Exclusion Criteria

  • •Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)
  • •Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998)
  • •Have a serious intercurrent pathology
  • •Being a pregnant woman
  • •Being a woman of childbearing age without effective contraception.
  • •Being hospitalized under duress or on an outpatient basis in a care program
  • •Being under judicial protection (reinforced curatorship, guardianship)

Outcomes

Primary Outcomes

Cerebral activity modification during N-back task

Time Frame: Day 1

Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

Cerebral activity modification during Stroop task

Time Frame: Day 1

Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

Cerebral activity modification during switching task (Monsell et Mizon task )

Time Frame: Day 1

Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

Study Sites (1)

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