Factors Associated With Dual-Task Performance in Patients With Multiple Sclerosis
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- Gazi University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Modified Sensory Organization Test
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system. It is reported that 85% of patients with multiple sclerosis have gait disturbance, 88% balance, and 35-90% fatigue (1, 2, 3). In addition, 65% of patients are reported that their cognitive functions have regressed (4).
It is important to increase the independence of the MS patients in activities of daily living (ADL). Almost all of ADL requires many activities at the same time. For example, toothbrushing involves both the standing balance and the motor activity of the upper limb at the same time. It also requires cognitive tasks such as attention and focusing. Many activities that seem to be the only task are actually multitasking (5).
The aim of this study is to investigate the effects of motor and cognitive additional task on balance, mobility and upper limb performances in MS patients and to determine the factors associated with dual-task performance.
Detailed Description
Patients with MS between 0-5,5 score according to the Extended Disability Status Scale (EDSS) and healthy individuals of similar age and sex to patients will be included in the study. The balance, mobility, upper extremity performance, cognitive function, fatigue, physical activity level, mood, sleep quality, quality of life will be evaluated once. We will use descriptive statistics and t-tests to compare demographic characteristics between groups and for the categorical variables chi-square. Effect of the group (MS patients or healthy controls), condition (Single task and dual-task conditions), and group × condition interaction will be compared using two-way repeated measures ANOVA. We will examine the correlations between fatigue severity, physical activity level, mood, sleep quality, quality of life using Pearson bivariate correlations. The significance level is set at p\<0,05.
Investigators
Cagla Ozkul
Research Assistant
Gazi University
Eligibility Criteria
Inclusion Criteria
- •Participants who 18-65 years of age
- •MS patients who are ambulatory (Expanded Disability Status Scale score ≤ 5,5 ) in a stable phase of the disease, without relapses in the last 3 month.
Exclusion Criteria
- •Participants who have orthopedic, vision, hearing, or perception problems
Outcomes
Primary Outcomes
Modified Sensory Organization Test
Time Frame: Fifteen minutes
The Modified Sensory Organization Test, which is performed using computerized posturography, measures postural sway in response to 4 different sensory conditions is measured using a force platform. * Cognitive additional task (arithmetic) * Cognitive additional task (verbal)
Timed Up and Go Test
Time Frame: ten minutes
Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again. Cognitive additional task (arithmetic): Individuals will be asked to perform tasks by counting backward from 3 to 3 from 100. Cognitive additional task (verbal): Individuals will be asked to fulfill their duties by producing a vegetable-fruit name.
upper extremity function
Time Frame: ten minutes
9-Hole Peg Test * Cognitive additional task (arithmetic) * Cognitive additional task (verbal)
Secondary Outcomes
- Sleep Quality: PSQI(5-10 minutes)
- Fatigue Severity(Five minutes)
- selective attention(Five minutes)
- Mood(one minute)
- Balance Confidence(five minutes)
- Visual attention and task switching(Five minutes)
- cognitive function(thirty minutes)