Fertility Preservation for Transfeminine Adolescents Via Semen Cryopreservation or Testicular Sperm Extraction

Recruiting

• Conditions: Gender Dysphoria, Adolescent

• Registration Number: NCT06400199
• Lead Sponsor: Amsterdam UMC, location VUmc

Brief Summary

The goal of this observational cohort study is to identify and predict parameters for successful testicular sperm extraction (TESE) procedures or semen cryopreservation more accurately and to evaluate the decision making process and the experience of postponing or temporarily discontinuing puberty suppression to undergo successful fertility preservation. in transfeminine (assigned male at birth) adolescents. The main question\[s\] it aims to answer are:

* What is the optimal timing for fertility preservation before the start or after temporarily discontinuing puberty suppression puberty suppression

* How do transfeminine adolescents and their parents experience the decision making process of fertility preservation

* how do transfeminine adolescents and their parents experienced postponing or temporarily discontinuing puberty suppression to undergo successful fertility preservation?

Participants will be asked to use their medical data, answer a questionnaire or participate in a (online) interview.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-07-01
• Study First Submitted: 2023-11-01
• Status Verified: 2024-05
• Study First Submitted QC: 2024-05-01
• Last Update Submitted: 2024-05-01
• Study First Posted: 2024-05-06
• Last Update Posted: 2024-05-06
• Primary Completion: 2024-07-01
• Study Completion: 2024-07-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

• Before start of puberty suppresion with a wish for fertility preservation
• After discontinuing puberty suppersion before the start of hormone therapy

Exclusion Criteria

• Tanner stage > 4/5

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
What parameter is best in predicting successful fertility preservation (i.e. spermatazoa are present)	Most recent before the TESE of semen cryopreservation no longer than 3 months old	Serum SHBG

Secondary Outcome Measures

Name	Time	Method
How do adolescents and parents experience fertility preservation	1 month post fertility preservation	semi-structed interviews

Trial Locations

Locations (2)

Amsterdam UMC, location AMC; 🇳🇱 Amsterdam, Netherlands

Amsterdam UMC, Location VU Medical Center; 🇳🇱 Amsterdam, Netherlands