Succesfull Fertility Preservation for Transfeminine Adolescents Via Semen Cryopreservation or Testicular Sperm Extraction
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- What parameter is best in predicting successful fertility preservation (i.e. spermatazoa are present)
研究概览
简要总结
The goal of this observational cohort study is to identify and predict parameters for successful testicular sperm extraction (TESE) procedures or semen cryopreservation more accurately and to evaluate the decision making process and the experience of postponing or temporarily discontinuing puberty suppression to undergo successful fertility preservation. in transfeminine (assigned male at birth) adolescents. The main question[s] it aims to answer are:
- What is the optimal timing for fertility preservation before the start or after temporarily discontinuing puberty suppression puberty suppression
- How do transfeminine adolescents and their parents experience the decision making process of fertility preservation
- how do transfeminine adolescents and their parents experienced postponing or temporarily discontinuing puberty suppression to undergo successful fertility preservation?
Participants will be asked to use their medical data, answer a questionnaire or participate in a (online) interview.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 10 Years 至 18 Years（Child, Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Before start of puberty suppresion with a wish for fertility preservation
- •After discontinuing puberty suppersion before the start of hormone therapy
排除标准
- •Tanner stage > 4/5
结局指标
主要结局
What parameter is best in predicting successful fertility preservation (i.e. spermatazoa are present)
时间窗: Most recent before the TESE of semen cryopreservation no longer than 3 months old
Serum SHBG
次要结局
- How do adolescents and parents experience fertility preservation(1 month post fertility preservation)
研究者
J.A.F. Huirne
Prof. dr. J.A.F. Huirne
Amsterdam UMC, location VUmc