NCT00753051已完成不适用
Treatment of Clozapine-resistant Schizophrenia : Comparison Between Augmentation With Haloperidol and Electroconvulsive Therapy
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- PANSS , HAM-D , CGI , AIMS Scores
研究概览
简要总结
Clozapine treatment resistant schizophrenia is still prevalent.The effectiveness of augmenting clozapine : one augmenting with haloperidol and the other with electroconvulsive therapy should be determined.This study is a randomized control trial.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •schizophrenic patients diagnosed with schedules for clinical assessment in neuropsychiatry ( SCAN )in accordance with DSM-IV-TR or ICD-10
- •Resistant to at least 6 weeks of clozapine treatment in therapeutic dosage
- •Voluntary to participate the research protocol expressed by signing informed consent form
排除标准
- •Patient does not volunteer himself or herself
- •Patient is having epilepsy, DM, cardiac disease, autistic disorder and illiterate
- •Patient is deaf, blind , dumb to obstruct good communication
研究组 & 干预措施
1.
Active Comparator
clozapine as the main agent and it will be adjuncted by haloperidol
干预措施: clozapine+haloperidol (Drug)
2.
Active Comparator
clozapine as the main agent and it will be adjuncted by electroconvulsive therapy
干预措施: clozapine,electroconvulsive therapy (Drug)
结局指标
主要结局
PANSS , HAM-D , CGI , AIMS Scores
时间窗: every 4 weeks for 24 weeks
次要结局
未报告次要终点
研究者
Suchat Paholpak
Professor Doctor
Khon Kaen University
研究点 (1)
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